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  1. Content type: Research

    The ability to accurately classify cancer patients into risk classes, i.e. to predict the outcome of the pathology on an individual basis, is a key ingredient in making therapeutic decisions. In recent years g...

    Authors: Leonardo Vanneschi, Antonella Farinaccio, Giancarlo Mauri, Marco Antoniotti, Paolo Provero and Mario Giacobini

    Citation: BioData Mining 2011 4:12

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  2. Content type: Review

    Understanding complex systems often requires a bottom-up analysis towards a systems biology approach. The need to investigate a system, not only as individual components but as a whole, emerges. This can be do...

    Authors: Georgios A Pavlopoulos, Maria Secrier, Charalampos N Moschopoulos, Theodoros G Soldatos, Sophia Kossida, Jan Aerts, Reinhard Schneider and Pantelis G Bagos

    Citation: BioData Mining 2011 4:10

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  3. Content type: Methodology

    Copy number variants are >1 kb genomic amplifications or deletions that can be identified using array platforms. However, arrays produce substantial background noise that contributes to high false discovery ra...

    Authors: Britney L Grayson and Thomas M Aune

    Citation: BioData Mining 2011 4:8

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  4. Content type: Methodology

    Gene expression microarray data have been organized and made available as public databases, but the utilization of such highly heterogeneous reference datasets in the interpretation of data from individual tes...

    Authors: Sami K Kilpinen, Kalle A Ojala and Olli P Kallioniemi

    Citation: BioData Mining 2011 4:5

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  5. Content type: Research

    Several methods have been presented for the analysis of complex interactions between genetic polymorphisms and/or environmental factors. Despite the available methods, there is still a need for alternative met...

    Authors: Thorsten Lehr, Jing Yuan, Dirk Zeumer, Supriya Jayadev and Marylyn D Ritchie

    Citation: BioData Mining 2011 4:4

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  6. Content type: Research

    Measurements on gene level are widely used to gain new insights in complex diseases e.g. cancer. A promising approach to understand basic biological mechanisms is to combine gene expression profiles and classi...

    Authors: Christian W Martin, Anika Tauchen, Anke Becker and Tim W Nattkemper

    Citation: BioData Mining 2011 4:2

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  7. Content type: Research

    The present knowledge of protein structures at atomic level derives from some 60,000 molecules. Yet the exponential ever growing set of hypothetical protein sequences comprises some 10 million chains and this ...

    Authors: Marco Vassura, Pietro Di Lena, Luciano Margara, Maria Mirto, Giovanni Aloisio, Piero Fariselli and Rita Casadio

    Citation: BioData Mining 2011 4:1

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  8. Content type: Software article

    Initial genome-wide association study (GWAS) discoveries are being further explored through the use of large cohorts across multiple and diverse populations involving meta-analyses within large consortia and n...

    Authors: Sarah A Pendergrass, Scott M Dudek, Dana C Crawford and Marylyn D Ritchie

    Citation: BioData Mining 2010 3:10

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  9. Content type: Methodology

    A fundamental goal of human genetics is the discovery of polymorphisms that predict common, complex diseases. It is hypothesized that complex diseases are due to a myriad of factors including environmental exp...

    Authors: Alison A Motsinger-Reif, Sushamna Deodhar, Stacey J Winham and Nicholas E Hardison

    Citation: BioData Mining 2010 3:8

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  10. Content type: Research

    Growing interest and burgeoning technology for discovering genetic mechanisms that influence disease processes have ushered in a flood of genetic association studies over the last decade, yet little heritabili...

    Authors: Stephen D Turner, Scott M Dudek and Marylyn D Ritchie

    Citation: BioData Mining 2010 3:5

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  11. Content type: Software article

    Massively parallel sequencing allows for genome-wide hypothesis-free investigation of for instance transcription factor binding sites or histone modifications. Although nucleotide resolution detailed informati...

    Authors: Stefan Enroth, Robin Andersson, Claes Wadelius and Jan Komorowski

    Citation: BioData Mining 2010 3:4

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  12. Content type: Research

    Scientific data integration and computational service discovery are challenges for the bioinformatic community. This process is made more difficult by the separate and independent construction of biological da...

    Authors: Rex T Nelson, Shulamit Avraham, Randy C Shoemaker, Gregory D May, Doreen Ware and Damian DG Gessler

    Citation: BioData Mining 2010 3:3

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  13. Content type: Research

    Affymetrix GeneChips utilize 25-mer oligonucleotides probes linked to a silica surface to detect targets in solution. Mismatches due to single nucleotide polymorphisms (SNPs) can affect the hybridization betwe...

    Authors: Fenghai Duan, Mark A Pauley, Eliot R Spindel, Li Zhang and Robert B Norgren Jr

    Citation: BioData Mining 2010 3:2

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  14. Content type: Review

    The quantities of data obtained by the new high-throughput technologies, such as microarrays or ChIP-Chip arrays, and the large-scale OMICS-approaches, such as genomics, proteomics and transcriptomics, are bec...

    Authors: Georgios A Pavlopoulos, Theodoros G Soldatos, Adriano Barbosa-Silva and Reinhard Schneider

    Citation: BioData Mining 2010 3:1

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  15. Content type: Research

    Protein families could be related to each other at broad levels that group them as superfamilies. These relationships are harder to detect at the sequence level due to high evolutionary divergence. Sequence se...

    Authors: Khader Shameer, Paramasivam Nagarajan, Kumar Gaurav and Ramanathan Sowdhamini

    Citation: BioData Mining 2009 2:8

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Page 10 of 11

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