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  1. Content type: Methodology

    One important concept in traditional Chinese medicine (TCM) is "treating different diseases with the same therapy". In TCM practice, some patients with Rheumatoid Arthritis (RA) and some other patients with Co...

    Authors: Guang Zheng, Miao Jiang, Xiaojuan He, Jing Zhao, Hongtao Guo, Gao Chen, Qinglin Zha and Aiping Lu

    Citation: BioData Mining 2011 4:18

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  2. Content type: Research

    MicroRNAs (miRNAs) mediate posttranscriptional regulation of protein-coding genes by binding to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradat...

    Authors: Jun-ichi Satoh and Hiroko Tabunoki

    Citation: BioData Mining 2011 4:17

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  3. Content type: Research

    To make sense out of gene expression profiles, such analyses must be pushed beyond the mere listing of affected genes. For example, if a group of genes persistently display similar changes in expression levels...

    Authors: Pablo C Echeverría, Fedor Forafonov, Deo P Pandey, Guillaume Mühlebach and Didier Picard

    Citation: BioData Mining 2011 4:15

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  4. Content type: Methodology

    DNA methylation plays a very important role in the silencing of tumor suppressor genes in various tumor types. In order to gain a genome-wide understanding of how changes in methylation affect tumor growth, th...

    Authors: Shuying Sun, Yi-Wen Huang, Pearlly S Yan, Tim HM Huang and Shili Lin

    Citation: BioData Mining 2011 4:13

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  5. Content type: Research

    The ability to accurately classify cancer patients into risk classes, i.e. to predict the outcome of the pathology on an individual basis, is a key ingredient in making therapeutic decisions. In recent years g...

    Authors: Leonardo Vanneschi, Antonella Farinaccio, Giancarlo Mauri, Marco Antoniotti, Paolo Provero and Mario Giacobini

    Citation: BioData Mining 2011 4:12

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  6. Content type: Review

    Understanding complex systems often requires a bottom-up analysis towards a systems biology approach. The need to investigate a system, not only as individual components but as a whole, emerges. This can be do...

    Authors: Georgios A Pavlopoulos, Maria Secrier, Charalampos N Moschopoulos, Theodoros G Soldatos, Sophia Kossida, Jan Aerts, Reinhard Schneider and Pantelis G Bagos

    Citation: BioData Mining 2011 4:10

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  7. Content type: Methodology

    Copy number variants are >1 kb genomic amplifications or deletions that can be identified using array platforms. However, arrays produce substantial background noise that contributes to high false discovery ra...

    Authors: Britney L Grayson and Thomas M Aune

    Citation: BioData Mining 2011 4:8

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  8. Content type: Methodology

    Gene expression microarray data have been organized and made available as public databases, but the utilization of such highly heterogeneous reference datasets in the interpretation of data from individual tes...

    Authors: Sami K Kilpinen, Kalle A Ojala and Olli P Kallioniemi

    Citation: BioData Mining 2011 4:5

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  9. Content type: Research

    Several methods have been presented for the analysis of complex interactions between genetic polymorphisms and/or environmental factors. Despite the available methods, there is still a need for alternative met...

    Authors: Thorsten Lehr, Jing Yuan, Dirk Zeumer, Supriya Jayadev and Marylyn D Ritchie

    Citation: BioData Mining 2011 4:4

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  10. Content type: Research

    Measurements on gene level are widely used to gain new insights in complex diseases e.g. cancer. A promising approach to understand basic biological mechanisms is to combine gene expression profiles and classi...

    Authors: Christian W Martin, Anika Tauchen, Anke Becker and Tim W Nattkemper

    Citation: BioData Mining 2011 4:2

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  11. Content type: Research

    The present knowledge of protein structures at atomic level derives from some 60,000 molecules. Yet the exponential ever growing set of hypothetical protein sequences comprises some 10 million chains and this ...

    Authors: Marco Vassura, Pietro Di Lena, Luciano Margara, Maria Mirto, Giovanni Aloisio, Piero Fariselli and Rita Casadio

    Citation: BioData Mining 2011 4:1

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  12. Content type: Software article

    Initial genome-wide association study (GWAS) discoveries are being further explored through the use of large cohorts across multiple and diverse populations involving meta-analyses within large consortia and n...

    Authors: Sarah A Pendergrass, Scott M Dudek, Dana C Crawford and Marylyn D Ritchie

    Citation: BioData Mining 2010 3:10

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  13. Content type: Methodology

    A fundamental goal of human genetics is the discovery of polymorphisms that predict common, complex diseases. It is hypothesized that complex diseases are due to a myriad of factors including environmental exp...

    Authors: Alison A Motsinger-Reif, Sushamna Deodhar, Stacey J Winham and Nicholas E Hardison

    Citation: BioData Mining 2010 3:8

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Page 10 of 12

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