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Table 3 Associations of imputed HLA alleles with SLE compared with RA

From: Machine learning approaches for the genomic prediction of rheumatoid arthritis and systemic lupus erythematosus

  SLE RA    95% CI
HLA alleles count % count % p value OR lower upper
DQA1*01:02 877 20.0 655 15.7 1.28E-07 1.35 1.21 1.51
DQA1*01:03 516 11.8 365 8.7 3.13E-06 1.40 1.21 1.61
DQA1*03:01 252 5.8 342 8.2 1.07E-05 0.69 0.58 0.81
DQA1*03:02 662 15.1 736 17.5 1.99E-03 0.83 0.74 0.94
DQA1*03:03 300 6.9 598 14.3 2.84E-29 0.44 0.38 0.51
DQA1*05:01 420 9.6 181 4.3 1.48E-21 2.35 1.96 2.81
DQA1*05:05 437 10.0 401 9.6 5.36E-01 1.05 0.91 1.21
DQA1*06:01 312 7.3 387 9.3 3.35E-04 0.75 0.64 0.88
DQB1*02:01 414 9.5 178 4.3 2.44E-21 2.35 1.96 2.82
DQB1*03:01 833 19.0 858 20.6 8.55E-02 0.91 0.82 1.01
DQB1*03:02 243 5.6 321 7.7 7.61E-05 0.71 0.6 0.84
DQB1*03:03 684 15.6 763 18.2 1.26E-03 0.83 0.74 0.93
DQB1*04:01 268 6.1 554 13.2 5.20E-29 0.43 0.37 0.5
DQB1*05:02 515 11.7 431 10.3 3.10E-02 1.16 1.01 1.33
DQB1*06:01 647 14.8 468 11.2 7.90E-07 1.38 1.21 1.56
DQB1*06:02 248 5.7 167 4.0 3.14E-04 1.44 1.18 1.77
DRB1*03:01 415 9.5 179 4.3 2.87E-21 2.34 1.96 2.81
DRB1*04:05 287 6.6 607 14.4 2.51E-33 0.41 0.36 0.48
DRB1*08:03 484 11.1 336 8.0 2.00E-06 1.42 1.23 1.65
DRB1*09:01 665 15.2 750 17.8 6.55E-04 0.82 0.73 0.92
DRB1*11:01 291 6.6 296 7.1 4.34E-01 0.94 0.79 1.11
DRB1*12:02 321 7.3 387 9.3 1.28E-03 0.78 0.67 0.91
DRB1*15:01 476 10.9 341 8.2 1.82E-05 1.37 1.19 1.59
DRB1*16:02 310 7.1 246 5.9 2.42E-02 1.22 1.03 1.45
  1. By Pearson’s chi-squared test. RA as a reference group. HLA: human leukocyte antigen; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; OR: odds ratio; CI: confidence interval