Skip to main content

Table 1 Genetic associations of the 85th/15th threshold ET genes with index diseases/traits (CEU-GIH-YRI)

From: Evolutionary triangulation: informing genetic association studies with evolutionary evidence

Index disease

ET genes

5tha

10tha

Odds ratiob

Lactase Persistence

LCT

Y

Y

Mendelian

Melanoma/Skin Neoplasms

OCA2

  

3.16 [58]

SLC45A2

Y

Y

2.78 [15]

TYRP1

  

1.15 [59]

XRCC1

  

0.60 [60]

Diabetes Mellitus, Type 2/Glucose Intolerance/Insulin Resistancec

ADAMTS9

  

1.12 [61]

DGKB

  

1.04 [62]

FTO

  

1.17 [63]

IDE

  

1.28 [64]

IGF2BP2

 

Y

1.22 [65]

IL6

 

Y

1.29 [66]

SH2B1

 

Y

1.16 [67]

SREBF1

 

Y

1.17 [68]

  1. a5th/10th: Y indicates ET genes identified under the 95th/5th or 90th/10th threshold, respectively
  2. bLargest reported Odds ratio
  3. cCase diagnosis is as defined in each reference
Back to article page

BioData Mining

ISSN: 1756-0381