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Table 1 Genetic associations of the 85th/15th threshold ET genes with index diseases/traits (CEU-GIH-YRI)

From: Evolutionary triangulation: informing genetic association studies with evolutionary evidence

Index disease ET genes 5tha 10tha Odds ratiob
Lactase Persistence LCT Y Y Mendelian
Melanoma/Skin Neoplasms OCA2    3.16 [58]
SLC45A2 Y Y 2.78 [15]
TYRP1    1.15 [59]
XRCC1    0.60 [60]
Diabetes Mellitus, Type 2/Glucose Intolerance/Insulin Resistancec ADAMTS9    1.12 [61]
DGKB    1.04 [62]
FTO    1.17 [63]
IDE    1.28 [64]
IGF2BP2   Y 1.22 [65]
IL6   Y 1.29 [66]
SH2B1   Y 1.16 [67]
SREBF1   Y 1.17 [68]
  1. a5th/10th: Y indicates ET genes identified under the 95th/5th or 90th/10th threshold, respectively
  2. bLargest reported Odds ratio
  3. cCase diagnosis is as defined in each reference