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Table 3 Results from dyadicity and heterophilicity analysis of the statistical epistasis network. Shown are the dyadicity and heterophilicity values for each of the twelve candidate obesity genes

From: Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity

Gene n 1 m 11 expected m 10 expected m 11 observed m 10 observed D H P-value D P-value H
FTO 324 28.399 319.157 21 301 0.739 0.943 0.85 0.727
MC4R 187 9.439 198.109 16 219 1.695 1.105 0.074 0.248
KCTD15 178 8.550 189.444 5 243 0.585 1.283 0.855 0.045
TMEM18 222 13.314 230.971 23 334 1.728 1.446 0.047 0.001
NEGR1 295 23.535 295.234 12 249 0.510 0.843 0.978 0.94
SH2B1 32 0.269 36.593 1 87 3.715 2.378 0.232 0.003
FAIM2 106 3.020 116.957 1 103 0.331 0.881 0.91 0.699
SEC16B 165 7.343 176.772 2 197 0.272 1.114 0.979 0.218
ETV5 168 7.613 179.713 3 173 0.394 0.963 0.952 0.596
BDNF 167 7.523 178.734 1 167 0.133 0.934 0.997 0.643
MTCH2 109 3.195 120.090 1 110 0.313 0.916 0.908 0.664
GNPDA2 186 9.338 197.151 1 125 0.107 0.634 1 0.997
  1. P-values were calculated from 1000 permutations. P-values <0.05 are highlighted in bold