Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity

Table 3 Results from dyadicity and heterophilicity analysis of the statistical epistasis network. Shown are the dyadicity and heterophilicity values for each of the twelve candidate obesity genes

Gene	n ₁	m _{11 expected}	m _{10 expected}	m _{11 observed}	m _{10 observed}	D	H	P-value_D	P-value_H
FTO	324	28.399	319.157	21	301	0.739	0.943	0.85	0.727
MC4R	187	9.439	198.109	16	219	1.695	1.105	0.074	0.248
KCTD15	178	8.550	189.444	5	243	0.585	1.283	0.855	0.045
TMEM18	222	13.314	230.971	23	334	1.728	1.446	0.047	0.001
NEGR1	295	23.535	295.234	12	249	0.510	0.843	0.978	0.94
SH2B1	32	0.269	36.593	1	87	3.715	2.378	0.232	0.003
FAIM2	106	3.020	116.957	1	103	0.331	0.881	0.91	0.699
SEC16B	165	7.343	176.772	2	197	0.272	1.114	0.979	0.218
ETV5	168	7.613	179.713	3	173	0.394	0.963	0.952	0.596
BDNF	167	7.523	178.734	1	167	0.133	0.934	0.997	0.643
MTCH2	109	3.195	120.090	1	110	0.313	0.916	0.908	0.664
GNPDA2	186	9.338	197.151	1	125	0.107	0.634	1	0.997

P-values were calculated from 1000 permutations. P-values <0.05 are highlighted in bold

ISSN: 1756-0381