Revealing third-order interactions through the integration of machine learning and entropy methods in genomic studies

Table 3 Test statistics and permutation testing results for ADNI dataset

SNP1	SNP2	SNP3	T_IG	P-value	Permutation p-value	Gene1	Gene2	Gene3
rs9366664	rs3780792	rs1150360	8.53	0.003	0.001	SYCP2L	VAV2	FAM76B
rs6705017	rs10017010	rs557098	7.51	0.006	0.001	UGGT1	PI4K2B	ALDH3B1
rs11749731	rs3780792	rs7157639	6.74	0.009	0.001	NDFIP1	VAV2	FERMT2
rs1023276	rs324389	rs2824808	8.81	0.002	0.002	-	NPSR1-AS1	TMPRSS15
rs6751810	rs4561856	rs1023276	7.92	0.004	0.002	-	-	-
rs4561856	rs4409091	rs2633466	7.61	0.005	0.002	-	-	-
rs4561856	rs10807701	rs2824808	7.55	0.005	0.002	-	TPST1	TMPRSS15
rs7091014	rs11006011	rs2633466	7.47	0.006	0.002	-	-	-
rs6856771	rs7157639	rs2824808	8.18	0.004	0.003	-	FERMT2	TMPRSS15
rs9366664	rs10960174	rs1150360	7.69	0.005	0.003	SYCP2L	-	FAM76B
rs11749731	rs10807701	rs7157639	7.42	0.006	0.003	NDFIP1	TPST1	FERMT2
rs6705017	rs11006011	rs2633466	7.77	0.005	0.005	UGGT1	-	-
rs9313264	rs12056012	rs2633466	7.69	0.005	0.005	-	-	-
rs6705017	rs2633466	rs462074	7.38	0.006	0.006	UGGT1	-	-
rs10017010	rs9313264	rs2207851	8.65	0.003	0.008	PI4K2B	-	PLAGL1
rs4561856	rs9896368	rs2824808	8.88	0.002	0.009	-	MMP28	TMPRSS15
rs4561856	rs7157639	rs717840	7.784	0.005	0.022	-	FERMT2	CDH13

ISSN: 1756-0381