Table 3 Association between SLE and SNPs among patients with high-titer ANA (≥ 1:640) at index date

VIT

rs13029062

0

429

Reference

Reference

1

285

1.24 (0.91, 1.68)

1.32 (0.95, 1.82)

2

55

3.06 (1.59, 6.38)**

3.00 (1.52, 6.39)**

rs71909377

0

343

Reference

Reference

1

342

1.38 (1.02, 1.87)*

1.49 (1.08, 2.06)*

2

84

2.19 (1.31, 3.76)**

2.53 (1.49, 4.44)***

rs62175694

0

550

Reference

Reference

1

201

1.54 (1.10, 2.17)*

1.54 (1.08, 2.21)*

2

18

2.63 (0.93, 9.37)

2.47 (0.82, 9.42)

SLC7A2

rs13268741

0

232

Reference

Reference

1

388

1.41 (1.01, 1.95)*

1.43 (1.01, 2.02)*

2

149

1.92 (1.25, 2.97)**

1.94 (1.24, 3.06)**

AUTS2

rs6971633

0

259

Reference

Reference

1

382

1.53 (1.11, 2.11)**

1.64 (1.17, 2.31)**

2

128

1.44 (0.94, 2.23)

1.49 (0.95, 2.36)

rs16905611

0

335

Reference

Reference

1

344

1.57 (1.15, 2.14)**

1.58 (1.15, 2.19)**

2

90

1.45 (0.90, 2.36)

1.35 (0.82, 2.25)

PACRG

rs6455889

0

324

Reference

Reference

1

357

0.92 (0.68, 1.26)

0.97 (0.70, 1.34)

2

88

0.51 (0.32, 0.82)**

0.53 (0.32, 0.88)*

rs9910586

0

438

Reference

Reference

1

289

0.81 (0.60, 1.10)

0.81 (0.59, 1.11)

2

42

0.48 (0.25, 0.92)*

0.49 (0.25, 0.95)*

rs712735

0

324

Reference

Reference

1

353

0.85 (0.62, 1.16)

0.78 (0.56, 1.08)

2

92

0.63 (0.40, 1.01)

0.59 (0.36, 0.97)*

rs5020365

0

245

Reference

Reference

1

365

0.74 (0.53, 1.04)

0.76 (0.53, 1.08)

2

159

0.50 (0.33, 0.75)***

0.50 (0.32, 0.77)**

rs4346053

0

414

Reference

Reference

1

296

0.69 (0.51, 0.94)*

0.72 (0.52, 0.99)*

2

59

0.71 (0.41, 1.23)

0.72 (0.40, 1.29)