Table 4 Hazard ratios from Cox proportional hazard models testing the prognostic role for all-cause mortality. Results are reported for the three genes considered separately (AHCY, DPYSL3, NME1) and for the score which combines the expression-based ranks of the three genes, considering the reversed rank for DPYSL3 since it showed RRs \(<1\). Abbreviations: HR, Hazard Ratio; CI, Confidence Interval; LR, Log-Rank

AHCY

GSE16476

1.99

1.29

3.07

0.002

3.56 \(\times 10^{-13}\)

AHCY

GSE62564

1.59

1.4

1.81

1.43 \(\times 10^{-12}\)

3.87 \(\times 10^{-43}\)

AHCY

E-MTAB-8248

1.68

1.35

2.1

3.61 \(\times 10^{-06}\)

6.25 \(\times 10^{-14}\)

AHCY

TARGET

1.12

0.883

1.42

0.353

0.004

AHCY

E-MTAB-38

2.49

1.87

3.31

4.96 \(\times 10^{-10}\)

9.03 \(\times 10^{-27}\)

AHCY

GSE85047

1.8

1.43

2.26

4.11 \(\times 10^{-07}\)

1.05 \(\times 10^{-19}\)

AHCY

Westermann

1.81

1.42

2.31

1.62 \(\times 10^{-06}\)

7.76 \(\times 10^{-08}\)

DPYSL3

GSE16476

0.47

0.321

0.689

1.07 \(\times 10^{-04}\)

2.45 \(\times 10^{-14}\)

DPYSL3

GSE62564

0.577

0.448

0.745

2.31 \(\times 10^{-05}\)

3.74 \(\times 10^{-28}\)

DPYSL3

E-MTAB-8248

0.577

0.38

0.877

0.01

3.35 \(\times 10^{-09}\)

DPYSL3

TARGET

0.744

0.546

1.01

0.0613

0.001

DPYSL3

E-MTAB-38

0.659

0.486

0.893

0.007

4.87 \(\times 10^{-14}\)

DPYSL3

GSE85047

0.729

0.592

0.897

0.003

4.30 \(\times 10^{-15}\)

DPYSL3

Westermann

0.639

0.491

0.832

0.001

4.37 \(\times 10^{-05}\)

NME1

GSE16476

1.38

0.934

2.04

0.105

1.46 \(\times 10^{-11}\)

NME1

GSE62564

1.4

1.24

1.57

2.89 \(\times 10^{-08}\)

4.21 \(\times 10^{-35}\)

NME1

E-MTAB-8248

1.55

1.17

2.05

0.002

4.22 \(\times 10^{-10}\)

NME1

TARGET

1.15

0.885

1.48

0.302

0.00319

NME1

E-MTAB-38

2.3

1.72

3.08

2.33 \(\times 10^{-08}\)

2.34 \(\times 10^{-24}\)

NME1

Westermann

1.52

1.14

2.03

0.004

1.52 \(\times 10^{-04}\)

Combined

GSE16476

2.23

1.4

3.55

0.001

9.82 \(\times 10^{-14}\)

Combined

GSE62564

2.92

2.25

3.79

1.12 \(\times 10^{-15}\)

1.73 \(\times 10^{-41}\)

Combined

E-MTAB-8248

2.25

1.55

3.25

1.7E \(\times 10^{-05}\)

5.79 \(\times 10^{-12}\)

Combined

TARGET

1.29

0.965

1.72

0.086

0.001

Combined

E-MTAB-38

3.24

2.14

4.92

3.22 \(\times 10^{-08}\)

8.35 \(\times 10^{-22}\)

Combined

Westermann

2.04

1.55

2.7

4.71 \(\times 10^{-07}\)

6.08 \(\times 10^{-08}\)