Table 3 Predicted LoF variants and genes in the GoNL. LoF genes column shows numbers of total LoF genes, one copy inactive genes (1-copy) and two copies inactive genes (2-copy). LoF variants shows total number of predicted LoF variants, heterozygous and homozygous variants
From: LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants and genes
| Â | LoF genes | LoF variants |
|---|---|---|
Total | 571 | 642 |
1-copy | 571 | - |
2-copy | 196 | - |
Median 1-copy per individual | 49 | - |
Median 2-copy per individual | 21 | - |
Heterozygous | - | 641 |
Homozygous | - | 213 |
Median heterozygous per individual | - | 54 |
Median homozygous per individual | - | 21 |