Fig. 2

Network of integrated interactions of proteins associated to our pan-cancer signature genes. Membership of proteins that interact with protein products of genes that are members of more than three (out of five) signatures. Four proteins (FANCD2, EEF1A1, YWHAE, PGLS) have PPIs with at least one protein products of genes in all signatures and one protein in breast cancer signature (ALDOC) interacts with all other four signatures. These five genes are shown with orange labels. Genes in different signatures are shown with different outline colors: grey for colorectal cancer, red for lung cancer, carbon blue for neuroblastoma, orange for breast cancer, and green for prostate cancer. Nodes with pink outline show interacting proteins with protein products of genes of different signatures. We produced this network with IID [56]