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Table 3 Associations between exposures related to energy balance and CRC risk in men and women, stratified for tertiles of the sex-specific polygenic risk score of mTOR-PI3K-Akt pathway polymorphisms in the Netherlands Cohort Study (20.3 years of follow-up)

From: Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

   Men Women
   BMI BMI
   T1 (sex-specific) T2 (sex-specific) T3 (sex-specific)   T1 (sex-specific) T2 (sex-specific) T3 (sex-specific)  
   N cases/PT at risk HR a,b (95% CI) N cases/PT at risk HR a,b (95% CI) N cases/PT at risk HR a,b (95% CI) P for interaction N cases/PT at risk HR a,b (95% CI) N cases/PT at risk HR a,b (95% CI) N cases/PT at risk HR a,b (95% CI) P for interaction
Polygenic risk score T1 165/3343 1.00 (ref.) 166/2911 1.07 (0.78,1.46) 203/2588 1.48 (1.08,2.04)   133/3207 1.00 (ref.) 141/2999 1.16 (0.83,1.62) 118/2788 1.03 (0.72,1.47)  
  T2 165/2907 1.00 (ref.) 207/3196 1.12 (0.82,1.52) 206/2810 1.26 (0.91,1.76)   139/2829 1.00 (ref.) 132/2822 0.98 (0.69,1.38) 109/2775 0.81 (0.55,1.17)  
  T3 186/2688 1.00 (ref.) 201/3046 0.93 (0.68,1.27) 219/2726 1.07 (0.77,1.47) 0.34 157/3000 1.00 (ref.) 137/2900 0.86 (0.62,1.20) 151/2746 1.04 (0.74,1.44) 0.54
   Trouser/skirt size Trouser/skirt size
   ≤median (sex-specific) >median (sex-specific)    ≤median (sex-specific) >median (sex-specific)   
   N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI)     P for interaction N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI)     P for interaction
Polygenic risk score T1 163/3250 1.00 (ref.) 321/5042 1.12 (0.81,1.54)      168/3967 1.00 (ref.) 220/4910 1.00 (0.69,1.45)     
  T2 176/2932 1.00 (ref.) 359/5019 1.17 (0.86,1.60)      176/3849 1.00 (ref.) 198/4437 1.03 (0.70,1.50)     
  T3 177/3062 1.00 (ref.) 376/4775 1.25 (0.92,1.71)     0.84 178/3628 1.00 (ref.) 263/4937 1.11 (0.79,1.56)     0.76
   Non-occupational physical activity Non-occupational physical activity
   ≤30 min/day >30-60 min/day >60 min/day   ≤30 min/day >30-60 min/day >60 min/day  
   N cases/PT at risk HR a,d (95% CI) N cases/PT at risk HR a,d (95% CI) N cases/PT at risk HR a,d (95% CI) P for interaction N cases/PT at risk HR a,d (95% CI) N cases/PT at risk HR a,d (95% CI) N cases/PT at risk HR a,d (95% CI) P for interaction
Polygenic risk score T1 89/1380 1.00 (ref.) 156/3011 0.79 (0.54,1.17) 289/4452 1.01 (0.70,1.45)   113/1887 1.00 (ref.) 104/2964 0.57 (0.39,0.84) 175/4142 0.70 (0.49,0.99)  
  T2 83/1378 1.00 (ref.) 177/2811 1.09 (0.74,1.62) 318/4724 1.14 (0.80,1.65)   98/1775 1.00 (ref.) 128/2790 0.84 (0.57,1.24) 154/3860 0.72 (0.50,1.04)  
  T3 102/1341 1.00 (ref.) 182/2766 0.78 (0.53,1.16) 322/4353 0.86 (0.60,1.23) 0.66 102/1933 1.00 (ref.) 157/2815 1.10 (0.76,1.59) 186/3898 0.91 (0.64,1.29) 0.67
   Height,
T1 (sex-specific)
Height,
T2 (sex-specific)
Height,
T3 (sex-specific)
  Height,
T1 (sex-specific)
Height,
T2 (sex-specific)
Height,
T3 (sex-specific)
 
   N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) P for interaction N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) P for interaction
Polygenic risk score T1 169/3074 1.00 (ref.) 182/2862 1.24 (0.90,1.71) 183/2906 1.24 (0.91,1.71)   126/3605 1.00 (ref.) 144/3156 1.34 (0.96,1.88) 122/2233 1.70 (1.18,2.44)  
  T2 185/3205 1.00 (ref.) 189/2616 1.44 (1.04,1.98) 204/3093 1.30 (0.95,1.77)   133/3130 1.00 (ref.) 131/2905 1.00 (0.71,1.42) 116/2390 1.05 (0.72,1.52)  
  T3 181/2826 1.00 (ref.) 205/2987 1.14 (0.83,1.56) 220/2647 1.28 (0.93,1.76) 0.94 138/3285 1.00 (ref.) 162/2761 1.60 (1.13,2.26) 145/2600 1.57 (1.09,2.27) 0.30
   Exposure to energy restriction during childhood and adolescence as based on place of residence during the Hunger Winter Exposure to energy restriction during childhood and adolescence as based on place of residence during the Hunger Winter
   Non-Western area Western rural area Western city   Non-Western area Western rural area Western city  
   N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) P for interaction N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) N cases/PT at risk HR a,c (95% CI) P for interaction
Polygenic risk score T1 269/4418 1.00 (ref.) 73/1127 1.24 (0.82,1.86) 107/1918 0.98 (0.70,1.38)   201/4989 1.00 (ref.) 60/1182 1.42 (0.92,2.19) 108/2291 1.24 (0.88,1.75)  
  T2 305/4307 1.00 (ref.) 69/1230 0.85 (0.57,1.27) 112/1696 0.84 (0.60,1.19)   194/4413 1.00 (ref.) 63/1222 1.20 (0.79,1.82) 101/2333 1.02 (0.72,1.43)  
  T3 324/4194 1.00 (ref.) 74/946 1.15 (0.76,1.74) 108/1805 0.72 (0.50,1.02) 0.56 225/4412 1.00 (ref.) 70/1283 1.12 (0.75,1.67) 127/2462 1.04 (0.75,1.43) 0.61
  1. Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio; N, number of; PT, person-time; ref., reference; T1-3, tertile 1-3.
  2. a Adjusted for age (years), first-degree family history of colorectal cancer (yes/no); smoking status (never, ex, current); alcohol intake (0, 0.1-29, ≥30 g/d); meat intake (g/d), processed meat intake (g/d), and total energy intake (kcal/d).
  3. b Additionally adjusted for non-occupational physical activity (≤30, >30-60, >60 min/day), respectively.
  4. c Additionally adjusted for BMI (kg/m2) and non-occupational physical activity (≤30, >30-60, >60 min/day), respectively.
  5. d Additionally adjusted for BMI (kg/m2).