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Table 3 Associations between exposures related to energy balance and CRC risk in men and women, stratified for tertiles of the sex-specific polygenic risk score of mTOR-PI3K-Akt pathway polymorphisms in the Netherlands Cohort Study (20.3 years of follow-up)

From: Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

  

Men

Women

  

BMI

BMI

  

T1 (sex-specific)

T2 (sex-specific)

T3 (sex-specific)

 

T1 (sex-specific)

T2 (sex-specific)

T3 (sex-specific)

 
  

N cases/PT at risk

HR a,b

(95% CI)

N cases/PT at risk

HR a,b

(95% CI)

N cases/PT at risk

HR a,b

(95% CI)

P for interaction

N cases/PT at risk

HR a,b

(95% CI)

N cases/PT at risk

HR a,b

(95% CI)

N cases/PT at risk

HR a,b

(95% CI)

P for interaction

Polygenic risk score

T1

165/3343

1.00

(ref.)

166/2911

1.07

(0.78,1.46)

203/2588

1.48

(1.08,2.04)

 

133/3207

1.00

(ref.)

141/2999

1.16

(0.83,1.62)

118/2788

1.03

(0.72,1.47)

 
 

T2

165/2907

1.00

(ref.)

207/3196

1.12

(0.82,1.52)

206/2810

1.26

(0.91,1.76)

 

139/2829

1.00

(ref.)

132/2822

0.98

(0.69,1.38)

109/2775

0.81

(0.55,1.17)

 
 

T3

186/2688

1.00

(ref.)

201/3046

0.93

(0.68,1.27)

219/2726

1.07

(0.77,1.47)

0.34

157/3000

1.00

(ref.)

137/2900

0.86

(0.62,1.20)

151/2746

1.04

(0.74,1.44)

0.54

  

Trouser/skirt size

Trouser/skirt size

  

≤median (sex-specific)

>median (sex-specific)

  

≤median (sex-specific)

>median (sex-specific)

  
  

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

   

P for interaction

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

   

P for interaction

Polygenic risk score

T1

163/3250

1.00

(ref.)

321/5042

1.12

(0.81,1.54)

    

168/3967

1.00

(ref.)

220/4910

1.00

(0.69,1.45)

    
 

T2

176/2932

1.00

(ref.)

359/5019

1.17

(0.86,1.60)

    

176/3849

1.00

(ref.)

198/4437

1.03

(0.70,1.50)

    
 

T3

177/3062

1.00

(ref.)

376/4775

1.25

(0.92,1.71)

   

0.84

178/3628

1.00

(ref.)

263/4937

1.11

(0.79,1.56)

   

0.76

  

Non-occupational physical activity

Non-occupational physical activity

  

≤30 min/day

>30-60 min/day

>60 min/day

 

≤30 min/day

>30-60 min/day

>60 min/day

 
  

N cases/PT at risk

HR a,d

(95% CI)

N cases/PT at risk

HR a,d

(95% CI)

N cases/PT at risk

HR a,d

(95% CI)

P for interaction

N cases/PT at risk

HR a,d

(95% CI)

N cases/PT at risk

HR a,d

(95% CI)

N cases/PT at risk

HR a,d

(95% CI)

P for interaction

Polygenic risk score

T1

89/1380

1.00

(ref.)

156/3011

0.79

(0.54,1.17)

289/4452

1.01

(0.70,1.45)

 

113/1887

1.00

(ref.)

104/2964

0.57

(0.39,0.84)

175/4142

0.70

(0.49,0.99)

 
 

T2

83/1378

1.00

(ref.)

177/2811

1.09

(0.74,1.62)

318/4724

1.14

(0.80,1.65)

 

98/1775

1.00

(ref.)

128/2790

0.84

(0.57,1.24)

154/3860

0.72

(0.50,1.04)

 
 

T3

102/1341

1.00

(ref.)

182/2766

0.78

(0.53,1.16)

322/4353

0.86

(0.60,1.23)

0.66

102/1933

1.00

(ref.)

157/2815

1.10

(0.76,1.59)

186/3898

0.91

(0.64,1.29)

0.67

  

Height,

T1 (sex-specific)

Height,

T2 (sex-specific)

Height,

T3 (sex-specific)

 

Height,

T1 (sex-specific)

Height,

T2 (sex-specific)

Height,

T3 (sex-specific)

 
  

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

P for interaction

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

P for interaction

Polygenic risk score

T1

169/3074

1.00

(ref.)

182/2862

1.24

(0.90,1.71)

183/2906

1.24

(0.91,1.71)

 

126/3605

1.00

(ref.)

144/3156

1.34

(0.96,1.88)

122/2233

1.70

(1.18,2.44)

 
 

T2

185/3205

1.00

(ref.)

189/2616

1.44

(1.04,1.98)

204/3093

1.30

(0.95,1.77)

 

133/3130

1.00

(ref.)

131/2905

1.00

(0.71,1.42)

116/2390

1.05

(0.72,1.52)

 
 

T3

181/2826

1.00

(ref.)

205/2987

1.14

(0.83,1.56)

220/2647

1.28

(0.93,1.76)

0.94

138/3285

1.00

(ref.)

162/2761

1.60

(1.13,2.26)

145/2600

1.57

(1.09,2.27)

0.30

  

Exposure to energy restriction during childhood and adolescence as based on place of residence during the Hunger Winter

Exposure to energy restriction during childhood and adolescence as based on place of residence during the Hunger Winter

  

Non-Western area

Western rural area

Western city

 

Non-Western area

Western rural area

Western city

 
  

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

P for interaction

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

N cases/PT at risk

HR a,c

(95% CI)

P for interaction

Polygenic risk score

T1

269/4418

1.00

(ref.)

73/1127

1.24

(0.82,1.86)

107/1918

0.98

(0.70,1.38)

 

201/4989

1.00

(ref.)

60/1182

1.42

(0.92,2.19)

108/2291

1.24

(0.88,1.75)

 
 

T2

305/4307

1.00

(ref.)

69/1230

0.85

(0.57,1.27)

112/1696

0.84

(0.60,1.19)

 

194/4413

1.00

(ref.)

63/1222

1.20

(0.79,1.82)

101/2333

1.02

(0.72,1.43)

 
 

T3

324/4194

1.00

(ref.)

74/946

1.15

(0.76,1.74)

108/1805

0.72

(0.50,1.02)

0.56

225/4412

1.00

(ref.)

70/1283

1.12

(0.75,1.67)

127/2462

1.04

(0.75,1.43)

0.61

  1. Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio; N, number of; PT, person-time; ref., reference; T1-3, tertile 1-3.
  2. a Adjusted for age (years), first-degree family history of colorectal cancer (yes/no); smoking status (never, ex, current); alcohol intake (0, 0.1-29, ≥30 g/d); meat intake (g/d), processed meat intake (g/d), and total energy intake (kcal/d).
  3. b Additionally adjusted for non-occupational physical activity (≤30, >30-60, >60 min/day), respectively.
  4. c Additionally adjusted for BMI (kg/m2) and non-occupational physical activity (≤30, >30-60, >60 min/day), respectively.
  5. d Additionally adjusted for BMI (kg/m2).
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