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Table 2 Functions from CoV-Hipathia differentially activated in lung cell lines infected with SARS-CoV-2

From: Mechanistic modeling of the SARS-CoV-2 disease map

UniProt function UP/DOWN statistic p-valuea FDRb FCc logFC
Innate immunity UP 2.882 2.16E-03 0.018 1.048 0.067
Immunity UP 2.882 2.16E-03 0.018 1.019 0.028
Inflammatory response UP 2.882 2.16E-03 0.018 1.028 0.041
Antiviral defense UP 2.882 2.16E-03 0.018 1.192 0.253
Pyrogen UP 2.882 2.16E-03 0.018 1.177 0.235
Prostaglandin biosynthesis UP 2.882 2.16E-03 0.018 1.267 0.341
Prostaglandin metabolism UP 2.882 2.16E-03 0.018 1.267 0.341
Fatty acid biosynthesis UP 2.882 2.16E-03 0.018 1.266 0.341
Lipid biosynthesis UP 2.882 2.16E-03 0.018 1.266 0.341
Acute phase UP 2.882 2.16E-03 0.018 1.526 0.610
Osteogenesis UP 2.882 2.16E-03 0.018 1.181 0.241
Autophagy DOWN −2.722 4.33E-03 0.028 0.976 −0.035
Translation regulation UP 2.722 4.33E-03 0.028 1.015 0.022
Sphingolipid metabolism UP 2.722 4.33E-03 0.028 1.388 0.473
Necrosis UP 2.562 8.66E-03 0.046 1.009 0.013
Fibrinolysis UP 2.562 8.66E-03 0.046 1.103 0.141
Plasminogen activation UP 2.562 8.66E-03 0.046 1.072 0.101
  1. a P-value is calculated using Wilcoxon test
  2. b FDR refers to p-value adjusted for multiple comparisons using Benjamini and Hochberg method
  3. c FC means Fold Change
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