Mechanistic modeling of the SARS-CoV-2 disease map

Table 2 Functions from CoV-Hipathia differentially activated in lung cell lines infected with SARS-CoV-2

UniProt function	UP/DOWN	statistic	p-value^a	FDR^b	FC^c	logFC
Innate immunity	UP	2.882	2.16E-03	0.018	1.048	0.067
Immunity	UP	2.882	2.16E-03	0.018	1.019	0.028
Inflammatory response	UP	2.882	2.16E-03	0.018	1.028	0.041
Antiviral defense	UP	2.882	2.16E-03	0.018	1.192	0.253
Pyrogen	UP	2.882	2.16E-03	0.018	1.177	0.235
Prostaglandin biosynthesis	UP	2.882	2.16E-03	0.018	1.267	0.341
Prostaglandin metabolism	UP	2.882	2.16E-03	0.018	1.267	0.341
Fatty acid biosynthesis	UP	2.882	2.16E-03	0.018	1.266	0.341
Lipid biosynthesis	UP	2.882	2.16E-03	0.018	1.266	0.341
Acute phase	UP	2.882	2.16E-03	0.018	1.526	0.610
Osteogenesis	UP	2.882	2.16E-03	0.018	1.181	0.241
Autophagy	DOWN	−2.722	4.33E-03	0.028	0.976	−0.035
Translation regulation	UP	2.722	4.33E-03	0.028	1.015	0.022
Sphingolipid metabolism	UP	2.722	4.33E-03	0.028	1.388	0.473
Necrosis	UP	2.562	8.66E-03	0.046	1.009	0.013
Fibrinolysis	UP	2.562	8.66E-03	0.046	1.103	0.141
Plasminogen activation	UP	2.562	8.66E-03	0.046	1.072	0.101

^a P-value is calculated using Wilcoxon test
^b FDR refers to p-value adjusted for multiple comparisons using Benjamini and Hochberg method
^c FC means Fold Change

ISSN: 1756-0381