Table 2 KEGG pathway analysis of Eucommia ulmoides (EU)-Radix Achyranthis Bidentatae (RAB) in treating Osteoarthritis (OA) network
No. | Pathwy ID | Pathway name | P value | FDR | Count | Gene name |
|---|---|---|---|---|---|---|
1 | 04210 | Apoptosis | 7.20E-14 | 2.70E-12 | 15 | RELA,BCL2,FOS,CASP9,CASP3,NFKBIA,CASP8,BIRC5,PARP1,CTSD,IKBKB,MAPK8,CASP7,CYCS,MCL1 |
2 | 04151 | PI3K-Akt signaling pathway | 5.82E-08 | 2.05E-07 | 15 | RELA,EGFR,VEGFA,CCND1,BCL2,CASP9,IL6,PRKCA,ERBB2,MYC,NOS3,IGF2,IKBKB,GSK3B,MCL1 |
3 | 04668 | TNF signaling pathway | 2.09E-12 | 1.88E-11 | 13 | RELA,FOS,IL6,CASP3,NFKBIA,CASP8,ICAM1,SELE,VCAM1,IRF1,IKBKB,MAPK8,CASP7 |
4 | 04010 | MAPK signaling pathway | 3.31E-07 | 8.64E-07 | 13 | RELA,EGFR,VEGFA,FOS,CASP3,ELK1,PRKCA,ERBB2,MYC,HSPB1,IGF2,IKBKB,MAPK8 |
5 | 04657 | IL-17 signaling pathway | 1.99E-09 | 1.08E-08 | 10 | RELA,FOS,IL6,CASP3,NFKBIA,CASP8,IKBKB,MAPK8,GSK3B,FOSL1 |