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Table 1 Study Participant Demographics

From: An epistatic interaction between pre-natal smoke exposure and socioeconomic status has a significant impact on bronchodilator drug response in African American youth with asthma

    ViSEN Descriptive Statistics
Categorical Variable BDR
Responders
BDR
Non-Responders
p-value1 p-value2
Sample Size, N 118 115
Sex (% Female) 42% 42% 1.00 1.00
Age, yrs.
(Mean, [SE])
(14, [0.346]) (14, [0.323]) 0.67 0.373
Body Mass Index Obese 47 39 0.44 0.42
Non-Obese 71 76
Experience of Discrimination Yes 65 49 0.06 0.08
No 53 66
Pre-natal Smoke Exposure Yes 21 19 0.87 0.93
No 97 96
Socioeconomic Status > Low 81 73 0.41 0.49
Low 37 42
Air Pollution (NO2) ≥ Median 62 54 0.43 0.47
< Median 56 61
Global African Ancestry ≥ 80% 82 67 0.08 0.10
<  80% 36 48
  1. Summary statistics for all phenotypic data included for analysis in this study are presented above. The Bonferroni method was used to correct for multiple testing (threshold for statistical significance: permutation unadj. p ≤ 0.006 (0.05/8 tests)). P-values represent the significance of the main effects, of specified variables on BDR responder status. 1p-values calculated from ViSEN’s Mutual Information (MI) Test. MI is a metric that quantifies the reduction in uncertainty about the distribution of one variable given an understanding of the other; 2p-values calculated from the χ2 Test of Independence unless otherwise indicated; 3p-values calculated from Wilcoxon Rank Sum test