Table 4 Linear regression fit of the quantile-normalized centrality scores (Eq. 20) and the percentage of mouse pathway genes that are lethal
From: Revisiting the use of graph centrality models in biological pathway analysis
Centrality | term | estimate | std.error | statistic | p.value |
|---|---|---|---|---|---|
Degree | (Intercept) | 8.08e+00 | 5.86e-01 | 1.38e+01 | 1.19e-24 |
Degree | Coefficient | 1.14e-02 | 1.01e-02 | 1.13e+00 | 2.62e-01 |
Katz-Sink | (Intercept) | 1.08e+01 | 1.07e+00 | 1.01e+01 | 9.91e-17 |
Katz-Sink | Coefficient | -2.27e-02 | 1.79e-02 | -1.27e+00 | 2.08e-01 |
Katz-Source | (Intercept) | 1.32e+01 | 1.09e+00 | 1.21e+01 | 6.70e-21 |
Katz-Source | Coefficient | -5.63e-02 | 1.83e-02 | -3.08e+00 | 2.69e-03 |
Katz-Source-Sink | (Intercept) | 8.47e+00 | 6.78e-01 | 1.25e+01 | 4.66e-22 |
Katz-Source-Sink | Coefficient | 6.40e-03 | 1.17e-02 | 5.46e-01 | 5.86e-01 |
Lap-Sink | (Intercept) | 1.03e+01 | 1.15e+00 | 8.89e+00 | 4.62e-14 |
Lap-Sink | Coefficient | -1.06e-02 | 1.94e-02 | -5.48e-01 | 5.85e-01 |
Lap-Source | (Intercept) | 1.30e+01 | 1.15e+00 | 1.13e+01 | 3.82e-19 |
Lap-Source | Coefficient | -4.50e-02 | 1.93e-02 | -2.33e+00 | 2.20e-02 |
Lap-SSC | (Intercept) | 5.51e+00 | 7.05e-01 | 7.82e+00 | 5.70e-12 |
Lap-SSC | Coefficient | 6.65e-02 | 1.22e-02 | 5.46e+00 | 3.54e-07 |
PageRank-Sink | (Intercept) | 8.72e+00 | 1.05e+00 | 8.28e+00 | 1.17e-12 |
PageRank-Sink | Coefficient | 1.04e-02 | 1.74e-02 | 6.01e-01 | 5.50e-01 |
PageRank-Source | (Intercept) | 9.15e+00 | 1.15e+00 | 7.93e+00 | 4.85e-12 |
PageRank-Source | Coefficient | 8.83e-03 | 1.94e-02 | 4.56e-01 | 6.49e-01 |
PageRank-SSC | (Intercept) | 5.92e+00 | 5.84e-01 | 1.01e+01 | 5.26e-17 |
PageRank-SSC | Coefficient | 5.24e-02 | 1.01e-02 | 5.20e+00 | 1.09e-06 |
PageRank-Und | (Intercept) | 7.12e+00 | 5.26e-01 | 1.35e+01 | 2.81e-24 |
PageRank-Und | Coefficient | 2.67e-02 | 9.08e-03 | 2.94e+00 | 4.03e-03 |