Table 1 Linear regression fit of the quantile-normalized centrality scores (Eq. 20) and the percentage human pathway genes that are cancer-related
From: Revisiting the use of graph centrality models in biological pathway analysis
Centrality | term | estimate | std.error | statistic | p.value |
|---|---|---|---|---|---|
Degree | (Intercept) | 1.50e+01 | 1.30e+00 | 1.15e+01 | 4.98e-20 |
Degree | Coefficient | 1.37e-01 | 2.24e-02 | 6.11e+00 | 2.01e-08 |
Katz-Sink | (Intercept) | 2.55e+01 | 2.31e+00 | 1.11e+01 | 8.26e-19 |
Katz-Sink | Coefficient | 6.23e-03 | 3.93e-02 | 1.58e-01 | 8.74e-01 |
Katz-Source | (Intercept) | 2.84e+01 | 2.57e+00 | 1.10e+01 | 1.49e-18 |
Katz-Source | Coefficient | -5.97e-02 | 4.28e-02 | -1.39e+00 | 1.67e-01 |
Katz-SSC | (Intercept) | 1.45e+01 | 1.12e+00 | 1.30e+01 | 4.23e-23 |
Katz-SSC | Coefficient | 1.38e-01 | 1.93e-02 | 7.13e+00 | 1.64e-10 |
Lap-Sink | (Intercept) | 2.49e+01 | 1.89e+00 | 1.32e+01 | 1.92e-23 |
Lap-Sink | Coefficient | 1.65e-02 | 3.23e-02 | 5.12e-01 | 6.09e-01 |
Lap-Source | (Intercept) | 2.91e+01 | 2.50e+00 | 1.17e+01 | 8.94e-20 |
Lap-Source | Coefficient | -7.29e-02 | 4.14e-02 | -1.76e+00 | 8.18e-02 |
Lap-SSC | (Intercept) | 1.27e+01 | 1.03e+00 | 1.24e+01 | 8.89e-22 |
Lap-SSC | Coefficient | 1.78e-01 | 1.78e-02 | 9.99e+00 | 1.12e-16 |
PageRank-Sink | (Intercept) | 1.33e+01 | 2.28e+00 | 5.85e+00 | 7.09e-08 |
PageRank-Sink | Coefficient | 1.91e-01 | 3.86e-02 | 4.93e+00 | 3.43e-06 |
PageRank-Source | (Intercept) | 1.27e+01 | 1.54e+00 | 8.23e+00 | 1.37e-12 |
PageRank-Source | Coefficient | 1.77e-01 | 2.55e-02 | 6.94e+00 | 5.88e-10 |
PageRank-SSC | (Intercept) | 7.58e+00 | 9.78e-01 | 7.76e+00 | 7.88e-12 |
PageRank-SSC | Coefficient | 2.67e-01 | 1.69e-02 | 1.58e+01 | 8.22e-29 |
PageRank-Und | (Intercept) | 9.06e+00 | 9.39e-01 | 9.65e+00 | 6.36e-16 |
PageRank-Und | Coefficient | 2.33e-01 | 1.62e-02 | 1.43e+01 | 6.49e-26 |