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Fig. 4 | BioData Mining

Fig. 4

From: Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

Fig. 4

Disease odds ratios conditioned on the genotype of 2 causal loci: Odds ratio effect sizes conditioned on pure epistatic pairs of loci for disease status in the simulated case-control datasets. Causal effects for DSL 1 and DSL 2 A are conditioned on allele A for DSL 1. The risk allele A of DSL 2 A only increases risk for individuals carrying at least one copy of the DSL 1 risk allele (DSL 1 is epistatic to DSL 2 A). The low risk CC/TT genotype is set as the baseline (OR=1). The other genotype combinations are coded according to g1,g2 and their product gg2. Odds ratio are obtained by exponentiating the β3 coefficient of the interaction term from the logistic regression (see text). Error bars: 95% confidence intervals of possible odds ratio that are obtained in different simulated case-control samples

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