Within-sample co-methylation patterns in normal tissues

Table 4 Contributions of each methylation state pair to chi-squared values (for 3S1T data)

	A	B	C	D	Total
1A	11.07	19.76	9.66	80.79
2A	81.88	90.94	169.23	133.90	1323.14
3A	128.16	162.92	85.94	348.87
1B	92.44	131.37	207.56	175.17
2B	0.13	8.90	19.73	1.08	1056.65
3B	66.29	170.44	69.79	113.76
1C	24.94	30.29	590.40	271.24
2C	6.05	3.55	1.87	4.80	1492.95
3C	43.97	7.89	369.10	138.87	1492.95
1D	64.76	423.16	4666.12	688.36
2D	127.42	191.84	1279.32	225.92	9013.65
3D	9.00	51.29	1148.63	137.81

Each cell corresponds to a methylation state pair. The row indicates the sample and initial methylation state. 1 corresponds to STL001 spleen, 2 to STL002 spleen, and 3 to STL003 spleen. The column indicates the terminal methylation state. Numerical values indicate the chi-squared contribution of a methylation state pair to the chi-squared test comparing all state pairs that begin with the same state (e.g., AA, AB, AC, AD). For example, the first number (11.07) is sample 1’s (STL001) AA pair’s contribution to the chi-squared test statistic (1323.14 in Table 3’s column A and Table 4’s last column)

ISSN: 1756-0381