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Table 2 Top 5 terms of the Gene Ontology, Pathway, and Disease enrichment of 38 CCT-associated genes

From: Functional relevance for central cornea thickness-associated genetic variants by using integrative analyses

Term Name P-value FDR B&H
GO: Molecular Function
 GO:0000988 transcription factor activity, protein binding 1.47E-04 3.62E-02
 GO:0005201 extracellular matrix structural constituent 4.54E-04 3.88E-02
 GO:0033293 monocarboxylic acid binding 4.72E-04 3.88E-02
 GO:0008013 beta-catenin binding 6.68E-04 4.13E-02
 GO:0000989 transcription factor activity, transcription factor binding 1.01E-03 4.96E-02
GO: Biological Process
 GO:0061448 connective tissue development 6.57E-07 9.12E-04
 GO:0072359 circulatory system development 3.05E-06 1.41E-03
 GO:0072358 cardiovascular system development 3.05E-06 1.41E-03
 GO:0001501 skeletal system development 6.12E-06 2.12E-03
 GO:0048646 anatomical structure formation involved in morphogenesis 2.15E-05 5.58E-03
GO: Cellular Component
 GO:0005604 basement membrane 5.18E-05 7.82E-03
 GO:0044420 extracellular matrix component 1.41E-04 1.06E-02
 GO:0016327 apicolateral plasma membrane 5.81E-04 1.84E-02
 GO:0043218 compact myelin 5.81E-04 1.84E-02
 GO:0005581 collagen trimer 6.08E-04 1.84E-02
Pathway
 M3005 Genes encoding collagen proteins 1.41E-04 3.09E-02
 1,470,926 Collagen chain trimerization 1.72E-04 3.09E-02
 83,105 Pathways in cancer 2.51E-04 3.09E-02
 M17668 Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation 3.41E-04 3.09E-02
 1,270,247 Assembly of collagen fibrils and other multimeric structures 3.56E-04 3.09E-02
Disease
 C0022578 Keratoconus 6.92E-11 8.68E-08
 C1096274 Corneal thinning 1.21E-05 7.56E-03
 C0544008 Chandler syndrom 6.00E-05 1.88E-02
 C1857569 Corneal endothelial dystrophy 2 6.00E-05 1.88E-02
 C3542501 Acute inflammatpry demyelinating polyneuropathy 1.12E-04 2.78E-02
  1. The list of CCT-associated genes was set as the input seed. Enrichment P-values were calculated using probability density function, and the Benjamini-Hochberg procedure was used to correct the P values (FDR) of the enriched GO terms