Table 2 Top 5 terms of the Gene Ontology, Pathway, and Disease enrichment of 38 CCT-associated genes
Term | Name | P-value | FDR B&H |
|---|---|---|---|
GO: Molecular Function | |||
 GO:0000988 | transcription factor activity, protein binding | 1.47E-04 | 3.62E-02 |
 GO:0005201 | extracellular matrix structural constituent | 4.54E-04 | 3.88E-02 |
 GO:0033293 | monocarboxylic acid binding | 4.72E-04 | 3.88E-02 |
 GO:0008013 | beta-catenin binding | 6.68E-04 | 4.13E-02 |
 GO:0000989 | transcription factor activity, transcription factor binding | 1.01E-03 | 4.96E-02 |
GO: Biological Process | |||
 GO:0061448 | connective tissue development | 6.57E-07 | 9.12E-04 |
 GO:0072359 | circulatory system development | 3.05E-06 | 1.41E-03 |
 GO:0072358 | cardiovascular system development | 3.05E-06 | 1.41E-03 |
 GO:0001501 | skeletal system development | 6.12E-06 | 2.12E-03 |
 GO:0048646 | anatomical structure formation involved in morphogenesis | 2.15E-05 | 5.58E-03 |
GO: Cellular Component | |||
 GO:0005604 | basement membrane | 5.18E-05 | 7.82E-03 |
 GO:0044420 | extracellular matrix component | 1.41E-04 | 1.06E-02 |
 GO:0016327 | apicolateral plasma membrane | 5.81E-04 | 1.84E-02 |
 GO:0043218 | compact myelin | 5.81E-04 | 1.84E-02 |
 GO:0005581 | collagen trimer | 6.08E-04 | 1.84E-02 |
Pathway | |||
 M3005 | Genes encoding collagen proteins | 1.41E-04 | 3.09E-02 |
 1,470,926 | Collagen chain trimerization | 1.72E-04 | 3.09E-02 |
 83,105 | Pathways in cancer | 2.51E-04 | 3.09E-02 |
 M17668 | Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation | 3.41E-04 | 3.09E-02 |
 1,270,247 | Assembly of collagen fibrils and other multimeric structures | 3.56E-04 | 3.09E-02 |
Disease | |||
 C0022578 | Keratoconus | 6.92E-11 | 8.68E-08 |
 C1096274 | Corneal thinning | 1.21E-05 | 7.56E-03 |
 C0544008 | Chandler syndrom | 6.00E-05 | 1.88E-02 |
 C1857569 | Corneal endothelial dystrophy 2 | 6.00E-05 | 1.88E-02 |
 C3542501 | Acute inflammatpry demyelinating polyneuropathy | 1.12E-04 | 2.78E-02 |