Fig. 3

Comparison of functional annotation scores of CCT-associated GWAS SNPs versus LD variants. a CADD scores for GWAS SNPs (n = 34) versus LD variants (n = 587); b GWAVA scores for GWAS SNPs (n = 41) versus LD variants (n = 654); c Eigen scores for GWAS SNPs (n = 43) versus LD variants (n = 645). In the boxplots, centerlines indicated the medians of the values and box limits showed the 25^th &75^th percentiles (as determined by R package). Whiskers extended to 5^th and 95^th percentiles and outliers were shown by open circle dots. The notches were defined as ±1.58 × IQR (interquartile range)/square root of n and indicated the 95% confidence interval for each median. P-values were calculated using two-sided Wilcoxon rank sum test