Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model

Table 2 Laboratory measurements and their strongly associated bacteria in OC-COPD. Bacteria that could not be classified to the genus level are listed at the lowest taxonomic level that could be confidently identified. Bacteria in bold are negatively associated with the laboratory measurement, indicating that higher microbial abundance is associated with lower measurement level

Percent Neutrophils (O1)	BUN (O2)	IGM (O3)	Partial Pressure of Oxygen (O4)	SAT (O5)	Alkaline Phosphatase (O6)	SGOT (O7)	SGPT (O8)	Cholesterol (O9)	Glucose (O10)
*Bacteroidales* (order)	*Aerococcaceae* (family)	Pseudomonas	*Bacillus*	*Bacillus*	*Bifidobacteriaceae* (family)	*Bacillales* (order)	*Rothia*	*Micrococcaceae* (family)	Rothia
S-24 (family in Bacteroidales order)	*Enterococcus*		Pseudomonas	Pseudomonas	*Weeksellaceae* (family)	*Lachnospiraceae* (family)	*Scardovia*	Porphyromonas	*Porphyromonas*
Clostridiaceae	*Streptococcus*				*Gemellales* (order)	*Moryella*	Clostridiales (order)	Prevotella	*Tannerella*
Oribacterium	Lachnospiraceae (family)				*Gemellaceae* (family)	Oribacterium	*Lachnospiraceae* (family)	Catonella	*Prevotella*
Oscillospira					*Granulicatella*	Peptostrepto-coccus	*Moryella*	Filifactor	*Gemellaceae* (family)
Ruminococcus					Lactobacillus	*Eikenella*	Oribacterium	Peptostreptococcus	Lactobacillus
Phascolactobacterium					Eikenella	*Neisseria*	*Schwartzia*	Mogibacteriaceae (family)	*Peptostrepto-coccaceae* (family)
Succinivibrio					*Neisseria*	*Cardiobacterium*	Succinivibrio	TG-5 (member of Dethiosulfovibronaceae family)	*Peptostrepto-coccus*
					Aggregatibacter			TM-7.3	Veillonella
								Mycoplasma	*Mogibacteriaceae* (family)
									*TG-5* (member of *Dethiosulfovibro-naceae* family)
									*Mycoplasma*

ISSN: 1756-0381