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Fig. 1 | BioData Mining

Fig. 1

From: Connecting genetics and gene expression data for target prioritisation and drug repositioning

Fig. 1

Genes differentially expressed in disease are enriched for genes genetically associated with the same disease. a Boxplots showing distributions of Fisher’s exact test p-values for genetic and transcriptomic gene sets overlaps from the same or different diseases. b ROC curve with 95% confidence intervals obtained using same or different disease as labels and significance of enrichment between genetic and transcriptomic gene sets as the ranking metric. c Barplot showing breakdown of diseases by therapeutic area for which there is a significant overlap between GWAS associations and genes differentially expressed

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