Fig. 1From: Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPiConceptual overview of the simulation process and experimental design. Assays were randomly sampled from the original data based on a desired number of assays and assay sources (slices) so that the simulated datasets contained a subset of assays with arbitrarily assigned sources and all of 426 chemicals present in the original dataset. Simulated datasets were imputed and ToxPi profiles were calculated, with an overall summed ToxPi score given for analysisBack to article page