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Table 6 Top 10 KEGG pathway enrichment results comparison between (A) single data set analysis and (B) joint analysis in Huntington’s disease

From: A novel joint analysis framework improves identification of differentially expressed genes in cross disease transcriptomic analysis

Term Count Enrichment Pvalue Bonferroni corrected P
(A) Single
 hsa03050:Proteasome 12 5.14E-07 1.21E-04
 hsa05010:Alzheimer’s disease 20 1.95E-05 0.004579209
 hsa05012:Parkinson’s disease 18 2.58E-05 0.006034046
 hsa05016:Huntington’s disease 19 3.66E-04 0.08242395
 hsa05033:Nicotine addiction 7 0.003777846 0.589128604
 hsa00190:Oxidative phosphorylation 13 0.004721495 0.671158323
 hsa04932:Non-alcoholic fatty liver disease (NAFLD) 14 0.00497103 0.689975889
 hsa05169:Epstein-Barr virus infection 15 0.013743654 0.9613094
 hsa04723:Retrograde endocannabinoid signaling 10 0.01471692 0.969321024
 hsa04728:Dopaminergic synapse 11 0.02422846 0.996860832
(B) Joint
 hsa05012:Parkinson’s disease 29 3.18E-13 7.59E-11
 hsa00190:Oxidative phosphorylation 27 2.90E-12 6.92E-10
 hsa05016:Huntington’s disease 32 4.34E-12 1.04E-09
 hsa05010:Alzheimer’s disease 29 2.33E-11 5.57E-09
 hsa04932:Non-alcoholic fatty liver disease (NAFLD) 22 2.14E-07 5.12E-05
 hsa03050:Proteasome 10 3.21E-05 0.007653523
 hsa01100:Metabolic pathways 73 5.47E-05 0.012999463
 hsa05169:Epstein-Barr virus infection 20 1.02E-04 0.024158392
 hsa04721:Synaptic vesicle cycle 10 5.70E-04 0.127417187
 hsa01200:Carbon metabolism 13 0.001156092 0.241540496