Table 1 Simulation parameters. Parameters for the type I error analysis and the power analysis simulations performed using SeqSIMLA2

Bin size assessed

Gene-sized bin: 25 kb (50 ± 10 variants) XL_Gene sized bin: 100 kb (200 ± 10 variants)

Gene-sized bin: 25 kb (50 ± 10 variants)

Pathway sized bin: 2–50 gene-sized bins (100–2500 ± 10 variants)

Number of simulations

1000

1000

Sample size

500 cases, 500 controls

500 cases, 500 controls

Disease prevalence

5 %

5 %

Number of causal variants

N/A

10

Odds ratio (OR)

1

1.25, 1.5,1.75, 2, 2.5, 3, 4, 5

Variant weighting

No weighting

No weighting

Control only weighting

Control only weighting

Minimum weighting

Minimum weighting

Maximum weighting

Maximum weighting

Overall weighting

Overall weighting

Statistical test

Logistic regression

Logistic regression

Wilcoxon

Wilcoxon