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Table 1 Simulation parameters. Parameters for the type I error analysis and the power analysis simulations performed using SeqSIMLA2

From: A biologically informed method for detecting rare variant associations

Testing parameter Type I error analysis Power analysis
Bin size assessed Gene-sized bin: 25 kb (50 ± 10 variants) XL_Gene sized bin: 100 kb (200 ± 10 variants) Gene-sized bin: 25 kb (50 ± 10 variants)
Pathway sized bin: 2–50 gene-sized bins (100–2500 ± 10 variants)
Number of simulations 1000 1000
Sample size 500 cases, 500 controls 500 cases, 500 controls
Disease prevalence 5 % 5 %
Number of causal variants N/A 10
Odds ratio (OR) 1 1.25, 1.5,1.75, 2, 2.5, 3, 4, 5
Variant weighting No weighting No weighting
Control only weighting Control only weighting
Minimum weighting Minimum weighting
Maximum weighting Maximum weighting
Overall weighting Overall weighting
Statistical test Logistic regression Logistic regression
Wilcoxon Wilcoxon