Fig. 9
From: Representing and querying disease networks using graph databases
Shortest path queries to explore relationships between a) the O15534 protein (PER1 gene) and b) the P20393 protein (REV-ErbA-alpha gene) and the circadian core genes, (Table 3). a In terms of distance in graph, the O15534 protein (PER1 gene) (red square), transcriptional repressor, is closer to O15055 (PER2), Q16526 (CRY1) and Q49AN0 (CRY2), (transcriptional repressors), than to O15516 (CLOCK), O00327 (ARNTL/BMAL1) and Q99743 (NPAS2), (transcriptional activators). The circadian core genes are shown by black squares. b The P20393 protein (REV-ErbA-alpha gene) (red square), suggested to be involved in the disruption of clock genes [27], can be seen 3 steps away from the O00327(ARNTL/BMAL1) and Q99743(NPAS2) core clock genes (black squares). Node colour: protein, blue. Edges: PPI association, red; sequence similarity relationship, grey