A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis

Table 1 Pedigree summary statistics and hierarchical affection status models

Pedigree structure
Families	46
Founders	147
Non-founders	219
Total number of individuals	366
Number of affected individuals	176
Number of BP-I individuals	168
Number of BP-II individuals	9
Number of SABP individuals	9
Number of RUDD individuals	12
Family size (average)	7.96
Generations (average)	2.74
Number of affected relative pairs	ASM1	ASM2	ASM3
1 degree	224	183	200
2 degree	106	99	91
3 degree	33	27	34
4 degree	6	8	10
5 degree	4	3	3
6 degree	2	2	2
Hierarchical affection status models (ASM)
Very narrow affection status model (ASM1)	BP-I and SABP
Narrow affection status model (ASM2)	BP-I and SABP and BP-II
Broad affection status model (ASM3)	BP-I and SABP and BP-II and RUDD

The table displays the summary statistics for the 46 pedigrees under the three different affection status models (ASMs). BP-I: Bipolar type 1, BP-II: Bipolar type 2, SABP: Schizoaffective bipolar type, RUDD: Recurrent unipolar depressive disorder. Individuals with a diagnosis of bipolar spectrum disorders that only apply to a certain ASM were coded as “unknown” under the other ASMs

ISSN: 1756-0381