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Table 1 Results for QMDR association analysis for continuous BMI outcome

From: Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR)

Rank Model SNP1 Chr:bp Gene1 SNP2 Chr:bp Gene2 Permuted P-Value Bonferroni corrected P-value Explicit epistasis P-value
1 rs17171686,rs1427463 rs17171686 7:40335451 C7orf10 rs1427463 17:59923044 POLG2 <0.00011 0.01 <0.001
2 rs12617233,rs1427463 rs12617233 2:58893502 FLJ30838 rs1427463 17:59923044 POLG2 <0.00012 0.01 0.012
3 rs749457,rs1799998 rs749457 2:96159671 ASTL rs1799998 8:143996602 CYP11B2 <0.00026 0.03 <0.001
4 rs12617233,rs12210959 rs12617233 2:58893502 FLJ30838 rs12210959 6:6121143 F13A1 <0.00038 0.04 0.003
5 rs3102976,rs997295 rs3102976 6:159110007 EZR rs997295 15:65803397 MAP2K5 <0.00046 0.05 <0.001
6 rs2268484,rs8038415 rs2268484 3:8748950 CAV3 rs8038415 15:97316957 IGF1R <0.00046 0.05 0.009
7 rs12617233,rs822682 rs12617233 2:58893502 FLJ30838 rs822682 12:51798711 SOAT2 <0.00061 0.06 0.018
  1. Seven signals reached a Bonferroni corrected P-value < 0.1. SNPs have been mapped to their corresponding genes using dbSNP (build 139) and SCANdb. SNP1 and SNP2 indicate the individual SNPs within a given SNP-SNP interaction model identified by QMDR. Chromosomal location of SNPs is noted in the following format - Chromosome: Base pair. P-values were calculated from a distribution built from 1000 permutations. P-values were also corrected using the Bonferroni method. Explicit epistasis P-values were calculated from a distribution built from 1000 permutations using the ‘explicit test of epistasis’