Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR)

Table 1 Results for QMDR association analysis for continuous BMI outcome

Rank	Model	SNP1	Chr:bp	Gene1	SNP2	Chr:bp	Gene2	Permuted P-Value	Bonferroni corrected P-value	Explicit epistasis P-value
1	rs17171686,rs1427463	rs17171686	7:40335451	C7orf10	rs1427463	17:59923044	POLG2	<0.00011	0.01	<0.001
2	rs12617233,rs1427463	rs12617233	2:58893502	FLJ30838	rs1427463	17:59923044	POLG2	<0.00012	0.01	0.012
3	rs749457,rs1799998	rs749457	2:96159671	ASTL	rs1799998	8:143996602	CYP11B2	<0.00026	0.03	<0.001
4	rs12617233,rs12210959	rs12617233	2:58893502	FLJ30838	rs12210959	6:6121143	F13A1	<0.00038	0.04	0.003
5	rs3102976,rs997295	rs3102976	6:159110007	EZR	rs997295	15:65803397	MAP2K5	<0.00046	0.05	<0.001
6	rs2268484,rs8038415	rs2268484	3:8748950	CAV3	rs8038415	15:97316957	IGF1R	<0.00046	0.05	0.009
7	rs12617233,rs822682	rs12617233	2:58893502	FLJ30838	rs822682	12:51798711	SOAT2	<0.00061	0.06	0.018

Seven signals reached a Bonferroni corrected P-value < 0.1. SNPs have been mapped to their corresponding genes using dbSNP (build 139) and SCANdb. SNP1 and SNP2 indicate the individual SNPs within a given SNP-SNP interaction model identified by QMDR. Chromosomal location of SNPs is noted in the following format - Chromosome: Base pair. P-values were calculated from a distribution built from 1000 permutations. P-values were also corrected using the Bonferroni method. Explicit epistasis P-values were calculated from a distribution built from 1000 permutations using the ‘explicit test of epistasis’

ISSN: 1756-0381