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Table 3 Summary of genes associated with chemotherapy agent-specified neuropathy from the literature review. Number of papers for each agent-specified neuropathy, number of genes associated with each agent-specified neuropathy and number of agent-specified neuropathies associated with each gene are shown. For the association between a gene and an agent-specified neuropathy, the number of relating papers is listed

From: Informative gene network for chemotherapy-induced peripheral neuropathy

 

Agent

P

T

P/T

B

B/V

Th

M

Cyt

P/F

P/S

T/G

P/F/L

P/F/I

Pr/V/M

P/C

P/F/I/L

R/Cyc/D/V/Pr

Genes

# of papers

21

19

5

2

1

2

1

1

2

1

1

2

2

1

1

1

1

(IPA symbols)

# of genes

26

19

7

7

17

6

3

1

1

1

1

2

1

2

0

0

0

 

# of agents

                 

GSTP1

6

7

1

      

1

1

 

1

1

    

ERCC1

2

2

 

1

              

ACYP2

1

2

                

FARS2

1

2

                

GSTM1

1

2

                

TAC1

1

2

                

ABCC2

2

1

1

               

ABCC1

2

1

                

ABCG2

1

1

                

AGXT

1

1

                

BTG4

1

1

                

CAMK2N1

1

1

                

CCNH

1

1

                

DLEU7

1

1

                

FOXC1

1

1

                

GMDS

1

1

                

GSTM3

1

1

                

ITGA1

1

1

                

ITGB3

1

1

                

KCNN3

1

1

                

LYRM4

1

1

                

PELO

1

1

                

POU2AF1

1

1

                

SCN10A

1

1

                

SCN4A

1

1

                

TSPYL6

1

1

                

CYP2C8

2

 

5

1

              

ABCB1

1

 

3

               

EPHA5

1

 

2

               

EPHA6

1

 

2

               

TUBB2A

1

 

2

               

CYP3A4

2

 

1

           

1

   

CYP3A5

2

 

1

           

1

   

ABCG1

1

 

1

               

CYP1B1

1

 

1

               

EPHA4

1

 

1

               

FANCD2

1

 

1

               

FGD4

1

 

1

               

FZD3

1

 

1

               

LIMK2

1

 

1

               

SLCO1B1

1

 

1

               

SPIDR

1

 

1

               

XKR4

1

 

1

               

ABCA1

2

  

1

  

1

           

BCL2

1

  

1

              

OPRM1

1

  

1

              

SOX10

1

  

1

              

TRPV1

1

  

1

              

CTLA4

1

                 

CTSS

1

                 

CYP17A1

1

                 

DYNC1I1

1

                 

GJC3

1

                 

PSMB1

1

                 

TCF4

1

                 

PPARD

2

     

1

           

ALOX12

1

    

1

            

AURKA

1

    

1

            

CASP9

1

    

1

            

CPT1C

1

    

1

            

DPYD

1

    

1

            

ERCC3

1

    

1

            

ERCC4

1

    

1

            

GLI1

1

    

1

            

IGF1R

1

    

1

            

MBL2

1

    

1

            

MKI67

1

    

1

            

MYO5A

1

    

1

            

RHOBTB2

1

    

1

            

SOD2

1

    

1

            

SOX8

1

    

1

            

GSTT1

1

     

1

           

ICAM1

1

     

1

           

SERPINB2

1

     

1

           

SLC12A6

1

     

1

           

ASTN2

1

      

1

          

IYD

1

      

1

          

PXDC1

1

      

1

          

NME1

1

       

1

         

RRM1

1

          

1

      

XRCC1

1

           

1

     
  1. P: Platinum; T: Taxane; P/T: Platinum/Taxane; B: Bortezomib; B/V: Bortezomib/Vincristine; Th: Thalidomide; M: Methotrexate; Cyt: Cytarabine; P/F: Platinum/Fluorouracil; P/S: Platinum/S-1; T/G: Taxane/Gemcitabine; P/F/L: Platinum/Fluorouracil/Leucovorin; P/F/I: Platinum/Fluorouracil/Irinotecan; Pr/V/M: Prednisone/Vincristine/Methotrexate; P/C: Platinum/Capecitabine; P/F/I/L: Platinum/Fluorouracil/Irinotecan/Leucovorin; R/Cyc/D/V/Pr: Rituximab/Cyclophosphamide/Doxorubicin/Vincristine/Prednisone
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ISSN: 1756-0381