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Table 7 A list of putative DDI-ADE pairs signaled in the EMR data

From: Mining severe drug-drug interaction adverse events using Semantic Web technologies: a case study

D1 (RxCUI) D2(RxCUI) P (MedDRA) ADE Name N(D1) N(D2) N(D1,D2) N(D1,P) N(D2,P N(D1,D2,P) Score(DI,D2,P)
Aspirin (1191) Simvastatin (36567) 10002906 Aortic stenosis 38149 7494 2926 104 34 15 4.991
Zocor (196503) Simvastatin (36567) 10038428 Renal disorder 10894 7494 1472 40 56 7 4.550
Simvastatin (36567) atorvastatin (83367) 10028417 Myasthenia gravis 7494 2841 828 42 10 5 4.409
Warfarin (11289) Digoxin (3407) 10013887 Dysathria 6330 1927 641 43 7 6 4.36
Aspirin (1191) Simvastatin (36567) 10015090 Epistaxis 38149 7494 2926 126 28 9 4.257
gabapentin (25480) Simvastatin (36567) 10019245 Hearing impsored 4683 7494 280 35 70 5 3.935
Plavix (174742) Simvastatin (36567) 10017955 Gastrointestinal heamorrhage 4769 7494 642 54 42 9 3.88
Aspirin (1191) clopidogrel (32968) 10037423 Pulmunary oedema 38149 1436 1291 142 8 8 3.338
Aspirin (1191) clopidogrel (32968) 10005191 Blister Dyspnoea exertion 38149 1436 1291 135 9 7 3.048
Amlodipine (17767) Simvastatin (36567) 10013971 Dyspnoea exertional 2786 7494 561 62 89 11 2995
Aspirin (1191) Simvastatin (36567) 10047924 Wheezing 38149 7494 2926 354 73 27 2.969
Lantus (261551) Simvastatin (36567) 10012680 Diabetic neuropathy 1883 7494 329 39 20 5 2.63
Aspirin (1191) clopidogrel (32968) 10038428 Renal disorder 38149 1436 1291 175 9 6 2.452
Lantus (261551) clopidogrel (32968) 10040882 Skin lesion 38149 1436 1291 269 21 16 2.024
Aspirin (1191) clopidogrel (32968) 10046555 Urinary retention 38149 1436 1291 292 16 11 1.757
Aspirin (1191) clopidogrel (32968) 10061623 Adverse drug reaction 38149 1436 1291 368 20 15 1.549
Simvastatin (36567) Norvasc (58927) 10017076 fracture 7494 3416 318 139 59 6 1.219
  1. D1 - drug1, D2 - drug 2, P - problem, N – number, and Score – enrichment score.