Table 7 A list of putative DDI-ADE pairs signaled in the EMR data
From: Mining severe drug-drug interaction adverse events using Semantic Web technologies: a case study
D1 (RxCUI) | D2(RxCUI) | P (MedDRA) | ADE Name | N(D1) | N(D2) | N(D1,D2) | N(D1,P) | N(D2,P | N(D1,D2,P) | Score(DI,D2,P) |
|---|---|---|---|---|---|---|---|---|---|---|
Aspirin (1191) | Simvastatin (36567) | 10002906 | Aortic stenosis | 38149 | 7494 | 2926 | 104 | 34 | 15 | 4.991 |
Zocor (196503) | Simvastatin (36567) | 10038428 | Renal disorder | 10894 | 7494 | 1472 | 40 | 56 | 7 | 4.550 |
Simvastatin (36567) | atorvastatin (83367) | 10028417 | Myasthenia gravis | 7494 | 2841 | 828 | 42 | 10 | 5 | 4.409 |
Warfarin (11289) | Digoxin (3407) | 10013887 | Dysathria | 6330 | 1927 | 641 | 43 | 7 | 6 | 4.36 |
Aspirin (1191) | Simvastatin (36567) | 10015090 | Epistaxis | 38149 | 7494 | 2926 | 126 | 28 | 9 | 4.257 |
gabapentin (25480) | Simvastatin (36567) | 10019245 | Hearing impsored | 4683 | 7494 | 280 | 35 | 70 | 5 | 3.935 |
Plavix (174742) | Simvastatin (36567) | 10017955 | Gastrointestinal heamorrhage | 4769 | 7494 | 642 | 54 | 42 | 9 | 3.88 |
Aspirin (1191) | clopidogrel (32968) | 10037423 | Pulmunary oedema | 38149 | 1436 | 1291 | 142 | 8 | 8 | 3.338 |
Aspirin (1191) | clopidogrel (32968) | 10005191 | Blister Dyspnoea exertion | 38149 | 1436 | 1291 | 135 | 9 | 7 | 3.048 |
Amlodipine (17767) | Simvastatin (36567) | 10013971 | Dyspnoea exertional | 2786 | 7494 | 561 | 62 | 89 | 11 | 2995 |
Aspirin (1191) | Simvastatin (36567) | 10047924 | Wheezing | 38149 | 7494 | 2926 | 354 | 73 | 27 | 2.969 |
Lantus (261551) | Simvastatin (36567) | 10012680 | Diabetic neuropathy | 1883 | 7494 | 329 | 39 | 20 | 5 | 2.63 |
Aspirin (1191) | clopidogrel (32968) | 10038428 | Renal disorder | 38149 | 1436 | 1291 | 175 | 9 | 6 | 2.452 |
Lantus (261551) | clopidogrel (32968) | 10040882 | Skin lesion | 38149 | 1436 | 1291 | 269 | 21 | 16 | 2.024 |
Aspirin (1191) | clopidogrel (32968) | 10046555 | Urinary retention | 38149 | 1436 | 1291 | 292 | 16 | 11 | 1.757 |
Aspirin (1191) | clopidogrel (32968) | 10061623 | Adverse drug reaction | 38149 | 1436 | 1291 | 368 | 20 | 15 | 1.549 |
Simvastatin (36567) | Norvasc (58927) | 10017076 | fracture | 7494 | 3416 | 318 | 139 | 59 | 6 | 1.219 |