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Table 2 Grade definitions in the CTCAE grading system

From: Mining severe drug-drug interaction adverse events using Semantic Web technologies: a case study

Grade Definition
Grade 1 Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated.
Grade 2 Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL*.
Grade 3 Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self care ADL**.
Grade 4 Life-threatening consequences; urgent intervention indicated.
Grade 5 Death related to AE.
  1. Note: Activities of Daily Living (ADL); *Instrumental ADL refer to preparing meals, shopping for groceries or clothes, using the telephone, managing money, etc.; **Self care ADL refer to bathing, dressing and undressing, feeding self, using the toilet, taking medications, and not bedridden.