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Table 1 Comparison of different prediction methods

From: A simple structure-based model for the prediction of HIV-1 co-receptor tropism

Method Sensitivity Specificity
geno2pheno 0.31 0.98
wetcat 0.63 0.98
T-CUP 0.68 0.98
T-CUP 2.0 0.70 0.98
Bozek et al.* 0.75* 0.96*
T-CUP 0.73 0.95
Bozek et al. 0.81 0.95
T-CUP 2.0 0.85 0.95
T-CUP 0.81 0.83
Bozek et al. 0.94 0.83
T-CUP 2.0 0.95 0.83
  1. Methods are evaluated on an independent test set of 74 sequences collected from the literature with experimentally validated tropism. *:The method of Bozek et al. does only provide results for a specificity ≤ 0.96.