Table 3 Kyoto Encyclopedia of Genes and Genomes (KEGG) defined biological pathways shared between iron status biomarkers and cognitive performance phenotypes
From: The multiscale backbone of the human phenotype network based on biological pathways
Iron biomarker pathways1 | Cognitive performance pathways2 | Common pathways3 | |||
|---|---|---|---|---|---|
[4142] | Lysosome | [5143] | African trypanosomiasis | [1100] | Metabolic pathways |
[1100] | Metabolic pathways | [5034] | Alcoholism | [3060] | Protein export |
[4978] | Mineral absorption | [5010] | Alzheimers disease | [4066] | HIF-1 signaling |
[3060] | Protein export | [5146] | Amoebiasis | [4151] | PI3K-Akt signaling |
[4060] | Cytokine-cytokine receptor interaction | [5142] | Chagas disease (American trypanosomiasis) | [4080] | Neuroactive ligand-receptor interaction |
[531] | Glycosaminoglycan degradation | [4961] | Endocrine and other factor-regulated calcium reabsorption | ||
[4066] | HIF-1 signaling | [650] | Butanoate metabolism | ||
[4080] | Neuroactive ligand-receptor interaction | [4020] | Calcium signaling | ||
[4151] | PI3K-Akt signaling | [5031] | Amphetamine addiction | ||
[4630] | Jak-STAT signaling | [4062] | Chemokine signaling | ||
[4120] | Ubiquitin mediated proteolysis | [280] | Valine leucine and isoleucine degradation | ||
[4713] | Circadian entrainment | ||||
[5030] | Cocaine addiction | ||||
[4060] | Cytokine-cytokine receptor interaction | ||||
[4728] | Dopaminergic synapse | ||||
[5014] | Amyotrophic lateral sclerosis (ALS) | ||||
[4144] | Endocytosis | ||||
[5169] | Epstein-Barr virus infection | ||||
[71] | Fatty acid metabolism | ||||
[4510] | Focal adhesion | ||||
[4727] | GABAergic synapse | ||||
[4540] | Gap junction | ||||
[4971] | Gastric acid secretion | ||||
[4724] | Glutamatergic synapse | ||||
[4912] | GnRH signaling | ||||
[4066] | HIF-1 signaling | ||||
[5016] | Huntingtons disease | ||||
[562] | Inositol phosphate metabolism | ||||
[4730] | Long-term depression | ||||
[4720] | Long-term potentiation | ||||
[310] | Lysine degradation | ||||
[4916] | Melanogenesis | ||||
[1100] | Metabolic pathways | ||||
[5032] | Morphine addiction | ||||
[4080] | Neuroactive ligand-receptor interaction | ||||
[5033] | Nicotine addiction | ||||
[4330] | Notch signaling | ||||
[670] | One carbon pool by folate | ||||
[4151] | PI3K-Akt signaling | ||||
[3320] | PPAR signaling | ||||
[4972] | Pancreatic secretion | ||||
[4146] | Peroxisome | ||||
[4070] | Phosphatidylinositol signaling system | ||||
[640] | Propanoate metabolism | ||||
[3060] | Protein export | ||||
[4723] | Retrograde endocannabinoid signaling | ||||
[5323] | Rheumatoid arthritis | ||||
[4970] | Salivary secretion | ||||
[4726] | Serotonergic synapse | ||||
[4721] | Synaptic vesicle cycle | ||||
[5322] | Systemic lupus erythematosus | ||||
[5202] | Transcriptional misregulation in cancer | ||||
[380] | Tryptophan metabolism | ||||
[4725] | Cholinergic synapse | ||||
[4270] | Vascular smooth muscle contraction | ||||
[4310] | Wnt signaling | ||||
[410] | beta-Alanine metabolism | ||||