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Table 3 Kyoto Encyclopedia of Genes and Genomes (KEGG) defined biological pathways shared between iron status biomarkers and cognitive performance phenotypes

From: The multiscale backbone of the human phenotype network based on biological pathways

Iron biomarker pathways1 Cognitive performance pathways2 Common pathways3
[4142] Lysosome [5143] African trypanosomiasis [1100] Metabolic pathways
[1100] Metabolic pathways [5034] Alcoholism [3060] Protein export
[4978] Mineral absorption [5010] Alzheimers disease [4066] HIF-1 signaling
[3060] Protein export [5146] Amoebiasis [4151] PI3K-Akt signaling
[4060] Cytokine-cytokine receptor interaction [5142] Chagas disease (American trypanosomiasis) [4080] Neuroactive ligand-receptor interaction
[531] Glycosaminoglycan degradation [4961] Endocrine and other factor-regulated calcium reabsorption   
[4066] HIF-1 signaling [650] Butanoate metabolism   
[4080] Neuroactive ligand-receptor interaction [4020] Calcium signaling   
[4151] PI3K-Akt signaling [5031] Amphetamine addiction   
[4630] Jak-STAT signaling [4062] Chemokine signaling   
[4120] Ubiquitin mediated proteolysis [280] Valine leucine and isoleucine degradation   
   [4713] Circadian entrainment   
   [5030] Cocaine addiction   
   [4060] Cytokine-cytokine receptor interaction   
   [4728] Dopaminergic synapse   
   [5014] Amyotrophic lateral sclerosis (ALS)   
   [4144] Endocytosis   
   [5169] Epstein-Barr virus infection   
   [71] Fatty acid metabolism   
   [4510] Focal adhesion   
   [4727] GABAergic synapse   
   [4540] Gap junction   
   [4971] Gastric acid secretion   
   [4724] Glutamatergic synapse   
   [4912] GnRH signaling   
   [4066] HIF-1 signaling   
   [5016] Huntingtons disease   
   [562] Inositol phosphate metabolism   
   [4730] Long-term depression   
   [4720] Long-term potentiation   
   [310] Lysine degradation   
   [4916] Melanogenesis   
   [1100] Metabolic pathways   
   [5032] Morphine addiction   
   [4080] Neuroactive ligand-receptor interaction   
   [5033] Nicotine addiction   
   [4330] Notch signaling   
   [670] One carbon pool by folate   
   [4151] PI3K-Akt signaling   
   [3320] PPAR signaling   
   [4972] Pancreatic secretion   
   [4146] Peroxisome   
   [4070] Phosphatidylinositol signaling system   
   [640] Propanoate metabolism   
   [3060] Protein export   
   [4723] Retrograde endocannabinoid signaling   
   [5323] Rheumatoid arthritis   
   [4970] Salivary secretion   
   [4726] Serotonergic synapse   
   [4721] Synaptic vesicle cycle   
   [5322] Systemic lupus erythematosus   
   [5202] Transcriptional misregulation in cancer   
   [380] Tryptophan metabolism   
   [4725] Cholinergic synapse   
   [4270] Vascular smooth muscle contraction   
   [4310] Wnt signaling   
   [410] beta-Alanine metabolism   
  1. Note: Numbers in square brackets “[ ]” represent KEGG database identifiers for indicated biological pathways.
  2. 1KEGG Pathways assigned to the Iron Status Biomarker Pathway.
  3. 2KEGG Pathways assigned to the Cognitive Performance Pathway.
  4. 3KEGG Pathways that are shared between the iron status biomarker and cognitive performance pathways.