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Table 1 Type I error rates for data generated under the null hypothesis of no genetic association (g 2 =0)

From: A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection

Trait status Familywise error rate (Type I)
Distributions Variances ST WT Rank_ST Rank_WT Log_ST Log_WT Rtn_ST Rtn_WT
Normal Equal 0.040 0.053 0.049 0.049 0.044 0.051 0.050 0.058
Normal Unequal 0.058 0.066 0.044 0.051 0.064 0.056 0.053 0.058
Chi-square Equal 0.045 0.036 0.052 0.051 0.055 0.038 0.058 0.056
Chi-square Unequal 0.053 0.057 0.048 0.052 0.051 0.054 0.043 0.047
t-distribution Equal 0.048 0.053 0.050 0.059 0.049 0.056 0.052 0.057
t-distribution Unequal 0.057 0.044 0.042 0.051 0.053 0.048 0.045 0.039
  1. Legend ST=Student’s t-test, WT=Welch’s t-test, Rank_ST (Rank_WT)=Student’s t-test (Welch’s t-test) on trait ranks, Log_ST (Log_WT)=Student’s t-test (Welch’s t-test) on log transformed trait, Rtn_ST (Rtn_WT)= Student’s t-test (Welch’s t-test) on trait rank transformed to normal.