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Table 1 Type I error rates for data generated under the null hypothesis of no genetic association (g 2 =0)

From: A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection

Trait status

Familywise error rate (Type I)

Distributions

Variances

ST

WT

Rank_ST

Rank_WT

Log_ST

Log_WT

Rtn_ST

Rtn_WT

Normal

Equal

0.040

0.053

0.049

0.049

0.044

0.051

0.050

0.058

Normal

Unequal

0.058

0.066

0.044

0.051

0.064

0.056

0.053

0.058

Chi-square

Equal

0.045

0.036

0.052

0.051

0.055

0.038

0.058

0.056

Chi-square

Unequal

0.053

0.057

0.048

0.052

0.051

0.054

0.043

0.047

t-distribution

Equal

0.048

0.053

0.050

0.059

0.049

0.056

0.052

0.057

t-distribution

Unequal

0.057

0.044

0.042

0.051

0.053

0.048

0.045

0.039

  1. Legend ST=Student’s t-test, WT=Welch’s t-test, Rank_ST (Rank_WT)=Student’s t-test (Welch’s t-test) on trait ranks, Log_ST (Log_WT)=Student’s t-test (Welch’s t-test) on log transformed trait, Rtn_ST (Rtn_WT)= Student’s t-test (Welch’s t-test) on trait rank transformed to normal.