Figure 6

Result Graph DS1. The result graph for DS1 generated from TMHMM transmembrane-helical information. After removing less weighted edge connections, the graph is given more clearly. Different nodes are given as representative motifs. Two possible node colours describe the predicted topology state (TM = transmembrane, nTM = none-transmembrane) based on previous work by Grunert and colleagues [14] for each motif closer. This distinguishes TM-typical from TM-non-typical graph present motifs. Coloured weighted edges can be assigned to a occurrence value of the pendant colour-scale. Ultimately, the graph makes clear how often different consecutive motifs occur. Highly occurring motifs are connected with red coloured edges. It is shown that always the same residues are recovered at the starting and ending position of a motif. Here alanine, leucine, glycine or valine are the most involved starting and ending residues which get a great importance in structure forming motifs. Finally, often accrued motifs become apparent in their function as “hub”-motif. For example LL3, LV3, VL3 and AL3 often occur within a MA with other motifs. This leads to the indispensability for building helical regions within the membrane environment.