Figure 3
From: Graph representation of high-dimensional alpha-helical membrane protein data
MA Extraction. Using of ‘TM’ helical information (red coloured) to create own statistical restrictive frames called motif-architecture (MA). Each MA consists of four consecutive motifs where X and Y of a motif XYn corresponds to one of the 20 canonical amino acids and n-1 defines the length of highly variable positions between X and Y by n = {4 - 7}. In the case of the bacteriorhodopsin trimer (PDB-Id: 1brr), seven transmembrane alpha-helices have been predicted by TMHMM. ‘TM’ helical information was used to search for MAs with strictly defined architecture size of four motifs.