Two-locus GxG Interactions | pOR | p-value | FDR | pRR | p-value | FDR | pChi | p-value | FDR |
---|---|---|---|---|---|---|---|---|---|
ATIC rs4673990+ MTHFD2 rs12196 | 3.9 (1.6–13.1) | 0.001* | 0.013* | 1.9 (1.2-4.1) | 0.001* | 0.027* | 6.1 (1.8-21.1) | <.001* | 0.002* |
ATIC rs4673990 + MTHFD2 5nt ins/16nt del | 3.7 (1.5-12.8) | 0.001* | 0.013* | 1.8 (1.1-3.6) | 0.003* | 0.032* | 6.0 (1.6-22.0) | <.001* | 0.002* |
MTHFD2 rs12196 + GART rs8971 | 2.8 (1.1-8.8) | 0.013* | 0.069 | 1.6 (0.9-3.4) | 0.016* | 0.050 | 5.5 (1.3-20.7) | 0.001* | 0.009* |
MTHFD2 5nt ins/16nt del + GART rs8971 | 2.6 (1.0-7.9) | 0.017* | 0.069 | 1.5 (0.9-2.7) | 0.017* | 0.050 | 5.0 (1.1-20.6) | 0.002* | 0.011* |
ATIC rs4673990 + GART rs8971 | 2.5 (1.1-8.8) | 0.027* | 0.071 | 1.4 (0.9-2.4) | 0.038* | 0.088 | 4.7 (1.1-19.2) | 0.009* | 0.019* |
ATIC rs2372536 + MTHFD2 5nt ins/16nt del | 2.5 (1.0-8.3) | 0.017* | 0.069 | 1.6 (1.0-3.6) | 0.006* | 0.041* | 5.0 (1.1-17.6) | 0.011* | 0.020* |
ATIC rs2372536 + MTHFD2 rs12196 | 2.4 (0.9-8.0) | 0.021* | 0.069 | 1.4 (1.0-3.0) | 0.033* | 0.088 | 5.6 (1.2-18.3) | 0.008* | 0.019* |
ATIC rs2372536 + GART rs8971 | 2.2 (0.8-6.5) | 0.032* | 0.074 | 1.5 (0.9-2.8) | 0.015* | 0.050 | 4.5 (0.8-28.2) | 0.012* | 0.020* |
SLC25A32 rs17803441 +ITPA rs2295553 | 2.4 (0.8-7.5) | 0.023* | 0.069 | 1.6 (1.0-2.8) | 0.013* | 0.050 | 4.2 (0.8-17.9) | 0.005* | 0.019* |
ATIC rs4673990 + SLC25A32 rs17803441 | 2.3 (0.8-8.2) | 0.039* | 0.081 | 1.4 (0.8-2.2) | 0.061 | 0.106 | 4.9 (0.9-30.9) | 0.009* | 0.019* |
MTHFD2 rs12196 + ITPA rs2295553 | 2.1 (0.9-7.1) | 0.047* | 0.090 | 1.4 (0.8-2.1) | 0.065 | 0.106 | 4.2 (1.0-16.0) | 0.025* | 0.034* |
ATIC rs4673990 + ITPA rs2295553 | 2.3 (0.7-7.1) | 0.074 | 0.101 | 1.4 (0.7-2.2) | 0.076 | 0.106 | 3.7 (0.9-13.2) | 0.045* | 0.059 |
MTHFD2 rs12196 + SLC25A32 rs17803441 | 2.2 (0.7-6.9) | 0.060 | 0.097 | 1.4 (0.8-2.3) | 0.067 | 0.106 | 5.2 (0.9-27.2) | 0.012* | 0.020* |
ATIC rs2372536 + SLC25A32 rs17803441 | 2.2 (0.7-6.1) | 0.056 | 0.097 | 1.3 (0.9-2.7) | 0.062 | 0.106 | 6.6 (0.9-37.9) | 0.008* | 0.019* |
MTHFD2 5nt ins/16nt del + MTHFD2 rs12196 | 2.0 (0.9-7.0) | 0.074 | 0.101 | 1.3 (0.9-2.2) | 0.088 | 0.115 | 5.2 (0.8-33.1) | 0.008* | 0.019* |
MTHFD2 5nt ins/16nt del +LC25A32 rs17803441 | 2.0 (0.6-5.9) | 0.077 | 0.101 | 1.3 (0.9-3.3) | 0.073 | 0.106 | 4.2 (0.7-25.5) | 0.015* | 0.023* |
MTHFD2 5nt ins/16nt del + ITPA rs2295553 | 1.9 (0.8-6.4) | 0.114 | 0.139 | 1.3 (0.9-2.6) | 0.129 | 0.160 | 3.9 (0.8-14.6) | 0.076 | 0.094 |
ATIC rs2372536 + ITPA rs2295553 | 1.9 (0.8-6.9) | 0.119 | 0.139 | 1.3 (0.9-2.2) | 0.182 | 0.201 | 3.9 (0.8-13.3) | 0.091 | 0.101 |
GART rs8971 + ITPA rs2295553 | 1.9 (0.8-8.9) | 0.186 | 0.195 | 1.3 (0.9-3.6) | 0.217 | 0.228 | 4.7 (0.8-16.1) | 0.124 | 0.130 |
ATIC rs2372536 + ATIC rs4673990 | 1.8 (0.7-5.3) | 0.131 | 0.145 | 1.2 (0.8-2.0) | 0.161 | 0.188 | 4.0 (0.7-23.3) | 0.089 | 0.101 |
GART rs8971 + SLC25A32 rs17803441 | 1.7 (0.4-9.9) | 0.227 | 0.227 | 1.2 (0.7-5.7) | 0.296 | 0.296 | 3.5 (0.4-19.1) | 0.156 | 0.156 |