Table 2 Simulated gene-gene interaction models with varying penetrance functions and minor allele frequencies

From: Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction

		Model 1			Model 2
	BB	Bb	bb		BB	Bb	bb
AA	0	0.1	0	AA	0	0	0.1
Aa	0.1	0	0.1	Aa	0	0.05	0
aa	0	0.1	0	aa	0.1	0	0
		(A) MAF=0.5				(B) MAF=0.5
		Model 3				Model 4
	BB	Bb	bb		BB	Bb	bb
AA	0.08	0.07	0.05	AA	0.09	0.05	0.02
Aa	0.1	0	0.1	Aa	0.08	0.09	0.01
aa	0.03	0.1	0.04	aa	0.03	0.01	0.03
		(C) MAF=0.25				(D) MAF=0.25

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ISSN: 1756-0381

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