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Figure 2 | BioData Mining

Figure 2

From: Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction

Figure 2

Panel A: gene-gene interaction network of 7 SNPs associated with susceptibility to active arthritis. Significant GxG interactions (FDR<0.05) are connected by line, and the strength of interaction is labeled with pOR. A larger pOR indicates a stronger interaction (thicker line) while a smaller pOR value indicates a relatively milder interaction (thinner lines). Panel B: ROC curve for risk scores derived from 82 significant two-locus interactions pooled from 34 SNPs. The risk score is significantly higher in patients with a poor response to MTX (active arthritis; inset).

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