Table 1 The large-scale human microRNA target networks

hsa-let-7a

244

1022

Transcriptional regulation by p53

593

2.69E-179

Viral myocarditis

113

1.21E-34

Cancer

206

1.31E-62

hsa-let-7b

242

1016

Transcriptional regulation by p53

594

1.83E-179

Viral myocarditis

113

9.32E-35

Cancer

206

7.66E-63

hsa-let-7c

243

1020

Transcriptional regulation by p53

593

2.49E-179

Viral myocarditis

113

1.11E-34

Cancer

206

1.10E-62

hsa-let-7d

145

885

Transcriptional regulation by RB/E2F

836

2.18E-252

Chronic myelogenous leukemia

72

1.95E-22

Cancer

130

9.68E-40

hsa-let-7e

236

1111

Transcriptional regulation by p53

575

8.90E-174

Viral myocarditis

116

1.20E-35

Cancer

175

1.86E-53

hsa-let-7f

244

1022

Transcriptional regulation by p53

593

2.69E-179

Viral myocarditis

113

1.21E-34

Cancer

206

1.31E-62

hsa-let-7g

245

1022

Transcriptional regulation by p53

593

2.69E-179

Viral myocarditis

113

1.21E-34

Cancer

206

1.31E-62

hsa-let-7i

245

1022

Transcriptional regulation by p53

593

2.69E-179

Viral myocarditis

113

1.21E-34

Cancer

206

1.31E-62

hsa-miR-9

352

1115

Transcriptional regulation by PPARa

340

5.28E-103

Hepatocellular carcinoma

72

1.69E-22

Cancer

171

3.50E-52

hsa-miR-17

195

961

Transcriptional regulation by RB/E2F

971

3.27E-293

Chronic myelogenous leukemia

92

2.83E-28

Cancer

181

3.58E-55

hsa-miR-19a

226

1094

Transcriptional regulation by RB/E2F

760

2.10E-229

Chronic myelogenous leukemia

113

1.26E-34

Cancer

253

7.04E-77

hsa-miR-19b

225

1094

Transcriptional regulation by RB/E2F

760

2.10E-229

Chronic myelogenous leukemia

113

1.26E-34

Cancer

253

7.04E-77

hsa-miR-20a

165

1038

Transcriptional regulation by RB/E2F

856

1.64E-258

Chronic myelogenous leukemia

87

6.09E-27

Cancer

85

3.33E-26

hsa-miR-20b

198

981

Transcriptional regulation by RB/E2F

962

2.35E-290

Chronic myelogenous leukemia

98

3.39E-30

Cancer

183

6.98E-56

hsa-miR-26a

148

672

Transcriptional regulation by RB/E2F

919

1.76E-277

Chronic myelogenous leukemia

107

6.15E-33

Cancer

181

3.20E-55

hsa-miR-26b

148

672

Transcriptional regulation by RB/E2F

919

1.76E-277

Chronic myelogenous leukemia

107

6.15E-33

Cancer

181

3.20E-55

hsa-miR-27a

229

1192

Transcriptional regulation by CREB

1022

2.23E-308

Chronic myelogenous leukemia

95

1.96E-29

Cancer

194

3.05E-59

hsa-miR-27b

261

1337

Transcriptional regulation by CREB

1022

2.23E-308

Chronic myelogenous leukemia

94

4.51E-29

Cancer

211

4.11E-64

hsa-miR-29a

119

543

Transcriptional regulation by Ets-domain family

430

4.36E-130

Glioma

85

3.46E-26

Cancer

139

1.41E-42

hsa-miR-29b

118

578

Transcriptional regulation by Ets-domain family

422

1.15E-127

Glioma

82

1.55E-25

Cancer

146

1.44E-44

hsa-miR-29c

118

543

Transcriptional regulation by Ets-domain family

430

4.36E-130

Glioma

85

3.46E-26

Cancer

139

1.41E-42

hsa-miR-30a

455

1494

Transcriptional regulation by RB/E2F

777

9.43E-235

Chronic myelogenous leukemia

86

1.11E-26

Cancer

195

2.39E-59

hsa-miR-30b

455

1480

Transcriptional regulation by RB/E2F

781

1.08E-235

Chronic myelogenous leukemia

87

7.01E-27

Cancer

188

1.92E-57

hsa-miR-30c

454

1495

Transcriptional regulation by RB/E2F

778

6.13E-235

Chronic myelogenous leukemia

86

1.15E-26

Cancer

191

3.63E-58

hsa-miR-30d

452

1491

Transcriptional regulation by RB/E2F

778

7.28E-235

Chronic myelogenous leukemia

86

1.01E-26

Cancer

195

1.96E-59

hsa-miR-30e

455

1481

Transcriptional regulation by RB/E2F

780

1.29E-235

Chronic myelogenous leukemia

87

7.25E-27

Cancer

188

2.05E-57

hsa-miR-32

261

905

Transcriptional regulation by RB/E2F

842

2.74E-254

Gastric cancer

80

8.85E-25

Cancer

157

4.19E-48

hsa-miR-92a

219

642

Transcriptional regulation by MEF2

335

1.51E-101

Viral myocarditis

59

1.62E-18

Epithelial-mesenchymal transition

83

7.76E-26

hsa-miR-92b

258

701

Transcriptional regulation by MEF2

328

1.59E-99

Viral myocarditis

60

1.23E-18

Cancer

94

3.97E-29

hsa-miR-93

195

958

Transcriptional regulation by RB/E2F

972

2.37E-293

Chronic myelogenous leukemia

92

2.47E-28

Cancer

181

2.77E-55

hsa-miR-96

142

688

Transcriptional regulation by Ets-domain family

407

3.42E-123

Viral myocarditis

36

1.06E-11

Cancer

106

1.37E-32

hsa-miR-98

162

671

Transcriptional regulation by Myb

549

4.73E-166

Viral myocarditis

85

2.66E-26

Cancer

126

1.42E-38

hsa-miR-101

188

806

Transcriptional regulation by AP-1

492

1.10E-148

Hepatocellular carcinoma

70

6.40E-22

Cancer

127

4.26E-39

hsa-miR-106b

164

1028

Transcriptional regulation by RB/E2F

854

7.21E-258

Chronic myelogenous leukemia

87

5.48E-27

Cancer

85

2.93E-26

hsa-miR-124

285

1346

Transcriptional regulation by RB/E2F

756

3.57E-228

Chronic myelogenous leukemia

83

9.34E-26

Cancer

185

1.90E-56

hsa-miR-137

288

941

Transcriptional regulation by MITF family

339

1.19E-102

Adult T cell lymphoma/leukemia

66

1.30E-20

Cancer

179

1.00E-54

hsa-miR-147

199

867

Transcriptional regulation by RB/E2F

805

4.06E-243

Chronic myelogenous leukemia

113

6.60E-35

Cancer

132

2.57E-40

hsa-miR-153

154

1019

Transcriptional regulation by Myb

507

2.35E-153

Multiple myeloma

60

6.44E-19

Cancer

174

4.31E-53

hsa-miR-218

155

830

Transcriptional regulation by AP-1

344

2.28E-104

Hepatocellular carcinoma

69

1.63E-21

Cancer

136

1.52E-41

hsa-miR-372

101

562

Transcriptional regulation by RB/E2F

1022

2.23E-308

Chronic myelogenous leukemia

85

1.90E-26

Cancer

144

2.75E-44

hsa-miR-429

123

634

Transcriptional regulation by RB/E2F

918

2.45E-277

Chronic myelogenous leukemia

76

1.71E-23

Cancer

130

5.28E-40

hsa-miR-495

156

601

Transcriptional regulation by Ets-domain family

431

2.14E-130

Rheumatoid arthritis

77

5.90E-24

Adipogenesis

79

1.32E-24

hsa-miR-506

394

1536

Transcriptional regulation by Ets-domain family

317

4.69E-96

Viral myocarditis

99

1.73E-30

Cancer

172

1.43E-52

hsa-miR-519a

281

1256

Transcriptional regulation by RB/E2F

811

5.32E-245

Chronic myelogenous leukemia

106

1.34E-32

Cancer

220

8.03E-67

hsa-miR-519b-3p

281

1256

Transcriptional regulation by RB/E2F

811

5.32E-245

Chronic myelogenous leukemia

106

1.34E-32

Cancer

220

8.03E-67

hsa-miR-519c-3p

281

1256

Transcriptional regulation by RB/E2F

811

5.32E-245

Chronic myelogenous leukemia

106

1.34E-32

Cancer

220

8.03E-67

hsa-miR-520a-3p

184

690

Transcriptional regulation by RB/E2F

1022

2.23E-308

Chronic myelogenous leukemia

94

6.95E-29

Cancer

146

1.12E-44

hsa-miR-520b

182

690

Transcriptional regulation by RB/E2F

1022

2.23E-308

Chronic myelogenous leukemia

94

6.95E-29

Cancer

146

1.12E-44

hsa-miR-520c-3p

182

690

Transcriptional regulation by RB/E2F

1022

2.23E-308

Chronic myelogenous leukemia

93

9.28E-29

Cancer

145

1.77E-44

hsa-miR-520d-3p

183

690

Transcriptional regulation by RB/E2F

1022

2.23E-308

Chronic myelogenous leukemia

94

6.95E-29

Cancer

146

1.12E-44

hsa-miR-520e

184

690

Transcriptional regulation by RB/E2F

1022

2.23E-308

Chronic myelogenous leukemia

94

6.95E-29

Cancer

146

1.12E-44

hsa-miR-603

252

1150

Transcriptional regulation by Ets-domain family

344

3.26E-104

Multiple myeloma

84

4.36E-26

Cancer

161

4.24E-49