Figure 2

Molecular network of miR-15a targets. By the "neighboring" network-search algorithm, KeyMolnet illustrated a highly complex network of miR-15a targets that has the most statistically significant relationship with the pathway of 'transcriptional regulation by myb'. Red nodes represent miR-15a direct target molecules predicted by Diana-microT 3.0, whereas white nodes exhibit additional nodes extracted automatically from the core contents of KeyMolnet to establish molecular connections. The molecular relation is indicated by solid line with arrow (direct binding or activation), solid line with arrow and stop (direct inactivation), solid line without arrow (complex formation), dash line with arrow (transcriptional activation), and dash line with arrow and stop (transcriptional repression). The transcription factor myb is highlighted by a blue circle.