Model |
XOR
|
BOX
|
MOD
|
---|
Genotype | AA | Aa | aa | AA | Aa | aa | AA | Aa | aa |
---|
BB
| y | x | y | x | x | x | x | y | y |
Bb
| x | z | x | x | y | y | x | x | y |
bb
| y | x | y | x | y | y | y | y | x |
- Cells marked "x" represent genotype combinations with lower risk. The values "x," "y," and "z" represent penetrance values with 0 < x < y ≤ z < 1 which were chosen to achieve the desired heritability. For XOR models with MAF = 0.5, z = y; for XOR models with MAF = 0.25, z > y to achieve no marginal effects at either locus.