Articles

Integrative analysis of genetic and epigenetic profiling of lung squamous cell carcinoma (LSCC) patients to identify smoking level relevant biomarkers

Incidence and mortality of lung cancer have dramatically decreased during the last decades, yet still approximately 160,000 deaths per year occurred in United States. Smoking intensity, duration, starting age,...

Authors: Bidong Ma, Zhiyou Huang, Qian Wang, Jizhou Zhang, Bin Zhou and Jiaohong Wu

RNSCLC-PRSP software to predict the prognostic risk and survival in patients with resected T_1-3N_0–2 M₀ non-small cell lung cancer

The clinical outcomes of patients with resected T_1-3N_0–2M₀ non-small cell lung cancer (NSCLC) with the same tumor-node-metastasis (TNM) stage are diverse. Although other prognostic factors and prognostic predicti...

Authors: Yunkui Zhang, YaoChen Li, Rongsheng Zhang, Yujie Zhang and Haitao Ma

ViSEAGO: a Bioconductor package for clustering biological functions using Gene Ontology and semantic similarity

The main objective of ViSEAGO package is to carry out a data mining of biological functions and establish links between genes involved in the study. We developed ViSEAGO in R to facilitate functional Gene Ontolog...

Authors: Aurélien Brionne, Amélie Juanchich and Christelle Hennequet-Antier

Disease associations depend on visit type: results from a visit-wide association study

Widespread adoption of Electronic Health Records (EHR) increased the number of reported disease association studies, or Phenome-Wide Association Studies (PheWAS). Traditional PheWAS studies ignore visit type (i.e...

Authors: Mary Regina Boland, Snigdha Alur-Gupta, Lisa Levine, Peter Gabriel and Graciela Gonzalez-Hernandez

Exploration of a diversity of computational and statistical measures of association for genome-wide genetic studies

The principal line of investigation in Genome Wide Association Studies (GWAS) is the identification of main effects, that is individual Single Nucleotide Polymorphisms (SNPs) which are associated with the trai...

Authors: Elisabetta Manduchi, Patryk R. Orzechowski, Marylyn D. Ritchie and Jason H. Moore

On the utilization of deep and ensemble learning to detect milk adulteration

Fraudulent milk adulteration is a dangerous practice in the dairy industry that is harmful to consumers since milk is one of the most consumed food products. Milk quality can be assessed by Fourier Transformed...

Authors: Habib Asseiss Neto, Wanessa L.F. Tavares, Daniela C.S.Z. Ribeiro, Ronnie C.O. Alves, Leorges M. Fonseca and Sérgio V.A. Campos

ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration

Tremendous amount of whole-genome sequencing data have been provided by large consortium projects such as TCGA (The Cancer Genome Atlas), COSMIC and so on, which creates incredible opportunities for functional...

Authors: Jia-Hao Bi, Yi-Fan Tong, Zhe-Wei Qiu, Xing-Feng Yang, John Minna, Adi F. Gazdar and Kai Song

Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants. In Genome-Wide Association Interactio...

Authors: Marc Joiret, Jestinah M. Mahachie John, Elena S. Gusareva and Kristel Van Steen

Innovative strategies for annotating the “relationSNP” between variants and molecular phenotypes

Characterizing how variation at the level of individual nucleotides contributes to traits and diseases has been an area of growing interest since the completion of sequencing the first human genome. Our unders...

Authors: Jason E. Miller, Yogasudha Veturi and Marylyn D. Ritchie

Within-sample co-methylation patterns in normal tissues

DNA methylation is an epigenetic event that may regulate gene expression. Because of this regulation role, aberrant DNA methylation is often associated with many diseases. Within-sample DNA co-methylation is t...

Authors: Lillian Sun and Shuying Sun

Characterizing human genomic coevolution in locus-gene regulatory interactions

Coevolution has been used to identify and predict interactions and functional relationships between proteins of many different organisms including humans. Current efforts in annotating the human genome increas...

Authors: Daniel Savel and Mehmet Koyutürk

Encodings and models for antimicrobial peptide classification for multi-resistant pathogens

Antimicrobial peptides (AMPs) are part of the inherent immune system. In fact, they occur in almost all organisms including, e.g., plants, animals, and humans. Remarkably, they show effectivity also against mu...

Authors: Sebastian Spänig and Dominik Heider

Testing the assumptions of parametric linear models: the need for biological data mining in disciplines such as human genetics

Authors: Jason H. Moore, Trudy F. C. Mackay and Scott M. Williams

Approximate kernel reconstruction for time-varying networks

Most existing algorithms for modeling and analyzing molecular networks assume a static or time-invariant network topology. Such view, however, does not render the temporal evolution of the underlying biologica...

Authors: Gregory Ditzler, Nidhal Bouaynaya, Roman Shterenberg and Hassan M. Fathallah-Shaykh

A biplot correlation range for group-wise metabolite selection in mass spectrometry

Analytic methods are available to acquire extensive metabolic information in a cost-effective manner for personalized medicine, yet disease risk and diagnosis mostly rely upon individual biomarkers based on st...

Authors: Youngja H Park, Taewoon Kong, James R. Roede, Dean P. Jones and Kichun Lee

Predicting opioid dependence from electronic health records with machine learning

The opioid epidemic in the United States is averaging over 100 deaths per day due to overdose. The effectiveness of opioids as pain treatments, and the drug-seeking behavior of opioid addicts, leads physicians...

Authors: Randall J. Ellis, Zichen Wang, Nicholas Genes and Avi Ma’ayan

Use case driven evaluation of open databases for pediatric cancer research

A plethora of Web resources are available offering information on clinical, pre-clinical, genomic and theoretical aspects of cancer, including not only the comprehensive cancer projects as ICGC and TCGA, but a...

Authors: Fleur Jeanquartier, Claire Jean-Quartier and Andreas Holzinger

Application of an interpretable classification model on Early Folding Residues during protein folding

Machine learning strategies are prominent tools for data analysis. Especially in life sciences, they have become increasingly important to handle the growing datasets collected by the scientific community. Mea...

Authors: Sebastian Bittrich, Marika Kaden, Christoph Leberecht, Florian Kaiser, Thomas Villmann and Dirk Labudde

Unified Cox model based multifactor dimensionality reduction method for gene-gene interaction analysis of the survival phenotype

One strategy for addressing missing heritability in genome-wide association study is gene-gene interaction analysis, which, unlike a single gene approach, involves high-dimensionality. The multifactor dimensio...

Authors: Seungyeoun Lee, Donghee Son, Yongkang Kim, Wenbao Yu and Taesung Park

Distributed retrieval engine for the development of cloud-deployed biological databases

The integration of cloud resources with federated data retrieval has the potential of improving the maintenance, accessibility and performance of specialized databases in the biomedical field. However, such an...

Authors: David Bouzaglo, Israel Chasida and Elishai Ezra Tsur

Knomics-Biota - a system for exploratory analysis of human gut microbiota data

Metagenomic surveys of human microbiota are becoming increasingly widespread in academic research as well as in food and pharmaceutical industries and clinical context. Intuitive tools for investigating experi...

Authors: Daria Efimova, Alexander Tyakht, Anna Popenko, Anatoly Vasilyev, Ilya Altukhov, Nikita Dovidchenko, Vera Odintsova, Natalya Klimenko, Robert Loshkarev, Maria Pashkova, Anna Elizarova, Viktoriya Voroshilova, Sergei Slavskii, Yury Pekov, Ekaterina Filippova, Tatiana Shashkova…

A fast forward 3D connection algorithm for mitochondria and synapse segmentations from serial EM images

It is becoming increasingly clear that the quantification of mitochondria and synapses is of great significance to understand the function of biological nervous systems. Electron microscopy (EM), with the nece...

Authors: Weifu Li, Jing Liu, Chi Xiao, Hao Deng, Qiwei Xie and Hua Han

Transition-transversion encoding and genetic relationship metric in ReliefF feature selection improves pathway enrichment in GWAS

ReliefF is a nearest-neighbor based feature selection algorithm that efficiently detects variants that are important due to statistical interactions or epistasis. For categorical predictors, like genotypes, th...

Authors: M. Arabnejad, B. A. Dawkins, W. S. Bush, B. C. White, A. R. Harkness and B. A. McKinney

Combining DNA methylation and RNA sequencing data of cancer for supervised knowledge extraction

In the Next Generation Sequencing (NGS) era a large amount of biological data is being sequenced, analyzed, and stored in many public databases, whose interoperability is often required to allow an enhanced ac...

Authors: Eleonora Cappelli, Giovanni Felici and Emanuel Weitschek

To know the objective is not (necessarily) to know the objective function

Authors: Moshe Sipper, Ryan J. Urbanowicz and Jason H. Moore

Grasping frequent subgraph mining for bioinformatics applications

Searching for interesting common subgraphs in graph data is a well-studied problem in data mining. Subgraph mining techniques focus on the discovery of patterns in graphs that exhibit a specific network struct...

Authors: Aida Mrzic, Pieter Meysman, Wout Bittremieux, Pieter Moris, Boris Cule, Bart Goethals and Kris Laukens

Functional relevance for central cornea thickness-associated genetic variants by using integrative analyses

The genetic architecture underlying central cornea thickness (CCT) is far from understood. Most of the CCT-associated variants are located in the non-coding regions, raising the difficulty of following functio...

Authors: Jing Zhang, Dan Wu, Yiqin Dai and Jianjiang Xu

Evolutionary methods for variable selection in the epidemiological modeling of cardiovascular diseases

The redundancy of information is becoming a critical issue for epidemiologists. High-dimensional datasets require new effective variable selection methods to be developed. This study implements an advanced evo...

Authors: Christina Brester, Jussi Kauhanen, Tomi-Pekka Tuomainen, Sari Voutilainen, Mauno Rönkkö, Kimmo Ronkainen, Eugene Semenkin and Mikko Kolehmainen

Protein folding prediction in the HP model using ions motion optimization with a greedy algorithm

The function of a protein is determined by its native protein structure. Among many protein prediction methods, the Hydrophobic-Polar (HP) model, an ab initio method, simplifies the protein folding prediction ...

Authors: Cheng-Hong Yang, Kuo-Chuan Wu, Yu-Shiun Lin, Li-Yeh Chuang and Hsueh-Wei Chang

A multi-objective gene clustering algorithm guided by apriori biological knowledge with intensification and diversification strategies

Biologists aim to understand the genetic background of diseases, metabolic disorders or any other genetic condition. Microarrays are one of the main high-throughput technologies for collecting information abou...

Authors: Jorge Parraga-Alava, Marcio Dorn and Mario Inostroza-Ponta

TRIQ: a new method to evaluate triclusters

Triclustering has shown to be a valuable tool for the analysis of microarray data since its appearance as an improvement of classical clustering and biclustering techniques. The standard for validation of tric...

Authors: David Gutiérrez-Avilés, Raúl Giráldez, Francisco Javier Gil-Cumbreras and Cristina Rubio-Escudero

PathCORE-T: identifying and visualizing globally co-occurring pathways in large transcriptomic compendia

Investigators often interpret genome-wide data by analyzing the expression levels of genes within pathways. While this within-pathway analysis is routine, the products of any one pathway can affect the activit...

Authors: Kathleen M. Chen, Jie Tan, Gregory P. Way, Georgia Doing, Deborah A. Hogan and Casey S. Greene

Integrative analysis of gene expression and methylation data for breast cancer cell lines

The deadly costs of cancer and necessity for an accurate method of early cancer detection have demanded the identification of genetic and epigenetic factors associated with cancer. DNA methylation, an epigenet...

Authors: Catherine Li, Juyon Lee, Jessica Ding and Shuying Sun

Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model

Human microbiome studies in clinical settings generally focus on distinguishing the microbiota in health from that in disease at a specific point in time. However, microbiome samples may be associated with dis...

Authors: Laura Tipton, Karen T. Cuenco, Laurence Huang, Ruth M. Greenblatt, Eric Kleerup, Frank Sciurba, Steven R. Duncan, Michael P. Donahoe, Alison Morris and Elodie Ghedin

Soft document clustering using a novel graph covering approach

In text mining, document clustering describes the efforts to assign unstructured documents to clusters, which in turn usually refer to topics. Clustering is widely used in science for data retrieval and organi...

Authors: Jens Dörpinghaus, Sebastian Schaaf and Marc Jacobs

Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi

The Toxicological Priority Index (ToxPi) is a method for prioritization and profiling of chemicals that integrates data from diverse sources. However, individual data sources (“assays”), such as in vitro bioas...

Authors: Kimberly T. To, Rebecca C. Fry and David M. Reif

Feature selection for gene prediction in metagenomic fragments

Computational approaches, specifically machine-learning techniques, play an important role in many metagenomic analysis algorithms, such as gene prediction. Due to the large feature space, current de novo gene...

Authors: Amani Al-Ajlan and Achraf El Allali

Gene set analysis methods: a systematic comparison

Gene set analysis is a valuable tool to summarize high-dimensional gene expression data in terms of biologically relevant sets. This is an active area of research and numerous gene set analysis methods have be...

Authors: Ravi Mathur, Daniel Rotroff, Jun Ma, Ali Shojaie and Alison Motsinger-Reif

Connecting genetics and gene expression data for target prioritisation and drug repositioning

Developing new drugs continues to be a highly inefficient and costly business. By repurposing an existing compound for a different indication, drug repositioning offers an attractive alternative to traditional...

Authors: Enrico Ferrero and Pankaj Agarwal

Improving machine learning reproducibility in genetic association studies with proportional instance cross validation (PICV)

Machine learning methods and conventions are increasingly employed for the analysis of large, complex biomedical data sets, including genome-wide association studies (GWAS). Reproducibility of machine learning...

Authors: Elizabeth R. Piette and Jason H. Moore

Collective feature selection to identify crucial epistatic variants

Machine learning methods have gained popularity and practicality in identifying linear and non-linear effects of variants associated with complex disease/traits. Detection of epistatic interactions still remai...

Authors: Shefali S. Verma, Anastasia Lucas, Xinyuan Zhang, Yogasudha Veturi, Scott Dudek, Binglan Li, Ruowang Li, Ryan Urbanowicz, Jason H. Moore, Dokyoon Kim and Marylyn D. Ritchie

Pairwise gene GO-based measures for biclustering of high-dimensional expression data

Biclustering algorithms search for groups of genes that share the same behavior under a subset of samples in gene expression data. Nowadays, the biological knowledge available in public repositories can be use...

Authors: Juan A. Nepomuceno, Alicia Troncoso, Isabel A. Nepomuceno-Chamorro and Jesús S. Aguilar-Ruiz

A novel joint analysis framework improves identification of differentially expressed genes in cross disease transcriptomic analysis

Detecting differentially expressed (DE) genes between disease and normal control group is one of the most common analyses in genome-wide transcriptomic data. Since most studies don’t have a lot of samples, res...

Authors: Wenyi Qin and Hui Lu

Investigating the parameter space of evolutionary algorithms

Evolutionary computation (EC) has been widely applied to biological and biomedical data. The practice of EC involves the tuning of many parameters, such as population size, generation count, selection size, an...

Authors: Moshe Sipper, Weixuan Fu, Karuna Ahuja and Jason H. Moore

Identification of influential observations in high-dimensional cancer survival data through the rank product test

Survival analysis is a statistical technique widely used in many fields of science, in particular in the medical area, and which studies the time until an event of interest occurs. Outlier detection in this co...

Authors: Eunice Carrasquinha, André Veríssimo, Marta B. Lopes and Susana Vinga

Scalable non-negative matrix tri-factorization

Matrix factorization is a well established pattern discovery tool that has seen numerous applications in biomedical data analytics, such as gene expression co-clustering, patient stratification, and gene-disea...

Authors: Andrej Čopar, Marinka žitnik and Blaž Zupan

An automated pipeline for bouton, spine, and synapse detection of in vivo two-photon images

In the nervous system, the neurons communicate through synapses. The size, morphology, and connectivity of these synapses are significant in determining the functional properties of the neural network. Therefo...

Authors: Qiwei Xie, Xi Chen, Hao Deng, Danqian Liu, Yingyu Sun, Xiaojuan Zhou, Yang Yang and Hua Han

Sparse generalized linear model with L ₀ approximation for feature selection and prediction with big omics data

Feature selection and prediction are the most important tasks for big data mining. The common strategies for feature selection in big data mining are L ₁, SCAD and MC+. However, none of...

Authors: Zhenqiu Liu, Fengzhu Sun and Dermot P. McGovern

TSPmap, a tool making use of traveling salesperson problem solvers in the efficient and accurate construction of high-density genetic linkage maps

Recent advances in nucleic acid sequencing technologies have led to a dramatic increase in the number of markers available to generate genetic linkage maps. This increased marker density can be used to improve...

Authors: J. Grey Monroe, Zachariah A. Allen, Paul Tanger, Jack L. Mullen, John T. Lovell, Brook T. Moyers, Darrell Whitley and John K. McKay

Cluster ensemble based on Random Forests for genetic data

Clustering plays a crucial role in several application domains, such as bioinformatics. In bioinformatics, clustering has been extensively used as an approach for detecting interesting patterns in genetic data...

Authors: Luluah Alhusain and Alaaeldin M. Hafez