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Table 5 Binary classification results on the Hiyama2010 dataset. We consider only the three genes AHCY, DPYSL3 and NME1. We report the mean scores of 100 executions with corresponding standard deviations, obtained through the Random Forests [35] algorithm. Positives: data of survived patients. Negatives: data of deceased patients. MCC: Matthews correlation coefficient. MCC: worst and minimum value \(= -1\) and best and maximum value \(= +1\). TP rate: true positive rate, sensitivity, recall. TN rate: true negative rate, specificity. PR: precision-recall curve. PPV: positive predictive value, precision. NPV: negative predictive value. ROC: receiver operating characteristic curve. AUC: area under the curve. F\(_1\) score, accuracy, TP rate, TN rate, PPV, NPV, PR AUC, ROC AUC: worst and minimum value \(= 0\) and best and maximum value \(= 1\). Confusion matrix threshold for TP rate, TN rate, PPV, and NPV: 0.5. Hiyama2010 dataset: GSE16237 [23]

From: Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma

 

MCC

F\(_1\) score

accuracy

TP rate

TN rate

PPV

NPV

PR AUC

ROC AUC

mean

+0.517

0.885

0.834

0.892

0.647

0.893

0.685

0.952

0.877

std. dev.

0.355

0.096

0.128

0.127

0.329

0.110

0.331

0.080

0.151