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Table 1 The output of predicted LoF variants from WES in UKBB. High-confidence LoF variants are listed in the first column, followed by their consequences in the second column. The third and fourth columns show frequencies of heterozygous and homozygous LoF variants, respectively. The rest of columns indicate the zygosity of LoF variants for each individual; 0 for not carrying LoF variant, 1 for heterozygous LoF variant and 2 for homozygous LoF variant

From: LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants and genes

SNP_ID

Consequence

heterozygous_LoF_frequency

homozygous_LoF_frequency

Sample 1

Sample 2

Sample 3

chr19_52300416_CT_C

frameshift_variant

0.386

0.539

1

1

2

chr7_21543345_G_T

stop_gained

0.499

0.250

0

1

1

chr10_72508273_T_C

splice_acceptor_variant

0.425

0.450

2

1

0

chr1_3602477_AC_A

frameshift_variant

4.98E-06

0

1

0

0

chr7_21543345_G_T

stop_gained

0.499

0.250

0

2

1