Table 1 Summary of Available Training Data for MCF7-Trained Classifiers
From: Predicting molecular initiating events using chemical target annotations and gene expression
MIE Name | MIE Active Profiles | MIE Active Chemicals | Exemplar Chemical Name | Exemplar Chemical DTXSID | Exemplar Chemical Support Level |
|---|---|---|---|---|---|
ABCB1 (−) | 283 | 25 | Quinidine | DTXSID4023549 | 20 |
ACE (−) | 57 | 6 | Fosinopril | DTXSID1023079 | 6 |
A/B-CHE (−) | 50 | 7 | NA | NA | NA |
ADRA1A (+) | 67 | 10 | Epinephrine | DTXSID5022986 | 10 |
ADRA2A (+) | 58 | 7 | Epinephrine | DTXSID5022986 | 8 |
ADRB-1/2 (−) | 67 | 8 | Nadolol | DTXSID3023342 | 5 |
ADRB-1/3 (+) | 51 | 6 | Epinephrine | DTXSID5022986 | 8 |
ADRB2 (+) | 55 | 9 | Epinephrine | DTXSID5022986 | 5 |
ALOX5 (−) | 51 | 5 | MK 886 | DTXSID5041067 | 5 |
APP (−) | 71 | 5 | NA | NA | NA |
AR (−) | 56 | 5 | Progesterone | DTXSID3022370 | 7 |
AR (+) | 52 | 8 | 17-Methyltestosterone | DTXSID1033664 | 10 |
CA-9/12 (−) | 76 | 10 | 4-(2-Aminoethyl)benzenesulfonamide | DTXSID20188814 | 10 |
CA-many (−) | 51 | 7 | NA | NA | NA |
CA-1/2 (−) | 90 | 13 | (RS)-(+/−)-sulpiride | DTXSID1042574 | 36 |
CYP19A1 (−) | 70 | 7 | Naringenin | DTXSID1022392 | 10 |
CYP2D6 (−) | 52 | 5 | Quinidine | DTXSID4023549 | 34 |
CYP3A4 (−) | 144 | 13 | Quinidine | DTXSID4023549 | 6 |
DHFR/TYMS (−) | 56 | 6 | Methotrexate | DTXSID4020822 | 43 |
DRD2 (−) | 118 | 14 | Haloperidol | DTXSID4034150 | 50 |
DRD2 (+) | 125 | 15 | Dopamine | DTXSID6022420 | 26 |
EGFR/ERBB2 (−) | 140 | 9 | Erlotinib | DTXSID8046454 | 55 |
ESR-1/2 (−) | 68 | 5 | Tamoxifen | DTXSID1034187 | 30 |
ESR-1/2 (+) | 145 | 12 | 17beta-Estradiol | DTXSID0020573 | 142 |
FLT1/KDR (−) | 122 | 10 | Erlotinib | DTXSID8046454 | 10 |
FLT3 (−) | 84 | 5 | NA | NA | NA |
HDAC (−) | 174 | 10 | MS-275 | DTXSID0041068 | 37 |
HMGCR (−) | 50 | 5 | Mevastatin | DTXSID4040684 | 14 |
HRH1 (−) | 110 | 14 | Astemizole | DTXSID9020110 | 5 |
HTR2A (−) | 67 | 8 | Haloperidol | DTXSID4034150 | 11 |
JAK2 (−) | 54 | 5 | NA | NA | NA |
KCNH2 (−) | 369 | 34 | Haloperidol | DTXSID4034150 | 14 |
KIT (−) | 88 | 5 | NA | NA | NA |
MAO-A/B (−) | 75 | 11 | Tranylcypromine | DTXSID2023694 | 10 |
MAPK14 (−) | 78 | 5 | NA | NA | NA |
MET (−) | 114 | 7 | Cabozantinib | DTXSID10233968 | 10 |
MTOR/PI3K (−) | 204 | 12 | Everolimus | DTXSID0040599 | 5 |
NR1I2 (+) | 50 | 6 | 17beta-Estradiol | DTXSID0020573 | 5 |
NR3C1 (+) | 100 | 10 | Clocortolone pivalate | DTXSID0045460 | 5 |
PDE3A (−) | 67 | 5 | Cilostamide | DTXSID3045140 | 5 |
PDE4-A/B/D (−) | 56 | 5 | Piclamilast | DTXSID3040227 | 9 |
PDGFRB (−) | 66 | 6 | Erlotinib | DTXSID8046454 | 9 |
PPAR-A/D/G (+) | 137 | 16 | Ciglitizone | DTXSID0040757 | 38 |
PTGS-1/2 (−) | 247 | 28 | Flurbiprofen | DTXSID0037231 | 14 |
SCN-1/2-A (−) | 51 | 5 | Lidocaine | DTXSID1045166 | 5 |
SCN5A (−) | 100 | 9 | Lidocaine | DTXSID1045166 | 6 |
SLC22A-1/2 (−) | 63 | 7 | Quinidine | DTXSID4023549 | 14 |
SLC22A6 (−) | 55 | 6 | Methotrexate | DTXSID4020822 | 6 |
SLC6A-2/3/4 (−) | 192 | 18 | Nisoxetine | DTXSID0045175 | 11 |
TOP2A (−) | 75 | 7 | Doxorubicin | DTXSID8021480 | 12 |
TUB (−) | 104 | 8 | Vinblastine | DTXSID8021430 | 12 |