|  |  | Men | Women |  |  | ||||
---|---|---|---|---|---|---|---|---|---|---|
Endpoint | Polygenic risk score a | PT at risk | N cases | HR b | (95% CI) | PT at risk | N cases | HR b | (95% CI) | |
CRC | T2 vs. T1 | 9796 vs. 9540 | 633 vs. 587 | 1.07 | (0.91,1.26) | 10,066 vs. 10,207 | 434 vs. 460 | 0.97 | (0.81,1.16) | |
 | T3 vs. T1 | 9506 vs. 9540 | 662 vs. 587 | 1.14 | (0.97,1.35) | 10,125 vs. 10,207 | 517 vs. 460 | 1.15 | (0.97,1.38) | |
 | Continuous | 28,841 | 1882 | 1.07 | (1.00,1.15) | 30,397 | 1411 | 1.09 | (1.01,1.17) | |
Colon | T2 vs. T1 | 9796 vs. 9540 | 397 vs. 376 | 1.05 | (0.87,1.27) | 10,066 vs. 10,207 | 312 vs. 337 | 0.95 | (0.78,1.16) | |
 | T3 vs. T1 | 9506 vs. 9540 | 444 vs. 376 | 1.20 | (1.00,1.44) | 10,125 vs. 10,207 | 395 vs. 337 | 1.21 | (1.00,1.46) | |
 | Continuous | 28,841 | 1217 | 1.10 | (1.03,1.19) | 30,397 | 1044 | 1.11 | (1.03,1.20) | |
Proximal colon | T2 vs. T1 | 9796 vs. 9540 | 177 vs. 175 | 1.02 | (0.80,1.30) | 10,066 vs. 10,207 | 185 vs. 200 | 0.96 | (0.76,1.21) | |
 | T3 vs. T1 | 9506 vs. 9540 | 213 vs. 175 | 1.24 | (0.98,1.57) | 10,125 vs. 10,207 | 232 vs. 200 | 1.20 | (0.96,1.51) | |
 | Continuous | 28,841 | 565 | 1.11 | (1.01,1.22) | 30,397 | 617 | 1.09 | (0.99,1.20) | |
Distal colon | T2 vs. T1 | 9796 vs. 9540 | 206 vs. 190 | 1.07 | (0.85,1.35) | 10,066 vs. 10,207 | 120 vs. 129 | 0.95 | (0.72,1.25) | |
 | T3 vs. T1 | 9506 vs. 9540 | 222 vs. 190 | 1.18 | (0.94,1.49) | 10,125 vs. 10,207 | 153 vs. 129 | 1.21 | (0.93,1.58) | |
 | Continuous | 28,841 | 618 | 1.11 | (1.02,1.22) | 30,397 | 402 | 1.14 | (1.02,1.27) | |
Rectum | T2 vs. T1 | 9796 vs. 9540 | 162 vs. 159 | 1.00 | (0.78,1.29) | 10,066 vs. 10,207 | 88 vs. 85 | 1.06 | (0.77,1.47) | |
 | T3 vs. T1 | 9506 vs. 9540 | 163 vs. 159 | 1.04 | (0.81,1.33) | 10,125 vs. 10,207 | 87 vs. 85 | 1.05 | (0.76,1.44) | |
 | Continuous | 28,841 | 484 | 1.00 | (0.91,1.11) | 30,397 | 260 | 1.07 | (0.94,1.22) |