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Table 2 Polygenic risk scores of mTOR-PI3K-Akt pathway polymorphisms in relation to CRC risk by sex and subsite in the Netherlands Cohort Study after 20.3 years of follow-up

From: Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

    Men Women   
Endpoint Polygenic risk score a PT at risk N cases HR b (95% CI) PT at risk N cases HR b (95% CI)
CRC T2 vs. T1 9796 vs. 9540 633 vs. 587 1.07 (0.91,1.26) 10,066 vs. 10,207 434 vs. 460 0.97 (0.81,1.16)
  T3 vs. T1 9506 vs. 9540 662 vs. 587 1.14 (0.97,1.35) 10,125 vs. 10,207 517 vs. 460 1.15 (0.97,1.38)
  Continuous 28,841 1882 1.07 (1.00,1.15) 30,397 1411 1.09 (1.01,1.17)
Colon T2 vs. T1 9796 vs. 9540 397 vs. 376 1.05 (0.87,1.27) 10,066 vs. 10,207 312 vs. 337 0.95 (0.78,1.16)
  T3 vs. T1 9506 vs. 9540 444 vs. 376 1.20 (1.00,1.44) 10,125 vs. 10,207 395 vs. 337 1.21 (1.00,1.46)
  Continuous 28,841 1217 1.10 (1.03,1.19) 30,397 1044 1.11 (1.03,1.20)
Proximal colon T2 vs. T1 9796 vs. 9540 177 vs. 175 1.02 (0.80,1.30) 10,066 vs. 10,207 185 vs. 200 0.96 (0.76,1.21)
  T3 vs. T1 9506 vs. 9540 213 vs. 175 1.24 (0.98,1.57) 10,125 vs. 10,207 232 vs. 200 1.20 (0.96,1.51)
  Continuous 28,841 565 1.11 (1.01,1.22) 30,397 617 1.09 (0.99,1.20)
Distal colon T2 vs. T1 9796 vs. 9540 206 vs. 190 1.07 (0.85,1.35) 10,066 vs. 10,207 120 vs. 129 0.95 (0.72,1.25)
  T3 vs. T1 9506 vs. 9540 222 vs. 190 1.18 (0.94,1.49) 10,125 vs. 10,207 153 vs. 129 1.21 (0.93,1.58)
  Continuous 28,841 618 1.11 (1.02,1.22) 30,397 402 1.14 (1.02,1.27)
Rectum T2 vs. T1 9796 vs. 9540 162 vs. 159 1.00 (0.78,1.29) 10,066 vs. 10,207 88 vs. 85 1.06 (0.77,1.47)
  T3 vs. T1 9506 vs. 9540 163 vs. 159 1.04 (0.81,1.33) 10,125 vs. 10,207 87 vs. 85 1.05 (0.76,1.44)
  Continuous 28,841 484 1.00 (0.91,1.11) 30,397 260 1.07 (0.94,1.22)
  1. Abbreviations: CRC, colorectal cancer; CI, confidence interval; HR, hazard ratio; PT, person-time; T1-3, sex-specific tertile 1-3; vs. versus.
  2. a The polygenic risk score was composed of MTOR rs1057079, TSC2 rs1800720, TSC2 rs2516739, PDK1 rs6723872, EIF4EBP1 rs6605631, RPS6KB2 rs12787021, AKT3 rs14403, AKT3 rs3006939, AKT3 rs946824, AKT2 rs16974157, AKT2 rs874269, and INSR rs891088 in men, and of MTOR rs2295080, TSC2 rs12918803, PDK1 rs6723872, RPS6KB2 rs12787021, AKT3 rs1352162, AKT3 rs14403, AKT3 rs7523198, AKT3 rs7523742, AKT2 rs16974157, AKT2 rs874269, and INSR rs891088 in women.
  3. b Adjusted for age (years).