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Table 2 Polygenic risk scores of mTOR-PI3K-Akt pathway polymorphisms in relation to CRC risk by sex and subsite in the Netherlands Cohort Study after 20.3 years of follow-up

From: Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

   

Men

Women

  

Endpoint

Polygenic risk score a

PT at risk

N cases

HR b

(95% CI)

PT at risk

N cases

HR b

(95% CI)

CRC

T2 vs. T1

9796 vs. 9540

633 vs. 587

1.07

(0.91,1.26)

10,066 vs. 10,207

434 vs. 460

0.97

(0.81,1.16)

 

T3 vs. T1

9506 vs. 9540

662 vs. 587

1.14

(0.97,1.35)

10,125 vs. 10,207

517 vs. 460

1.15

(0.97,1.38)

 

Continuous

28,841

1882

1.07

(1.00,1.15)

30,397

1411

1.09

(1.01,1.17)

Colon

T2 vs. T1

9796 vs. 9540

397 vs. 376

1.05

(0.87,1.27)

10,066 vs. 10,207

312 vs. 337

0.95

(0.78,1.16)

 

T3 vs. T1

9506 vs. 9540

444 vs. 376

1.20

(1.00,1.44)

10,125 vs. 10,207

395 vs. 337

1.21

(1.00,1.46)

 

Continuous

28,841

1217

1.10

(1.03,1.19)

30,397

1044

1.11

(1.03,1.20)

Proximal colon

T2 vs. T1

9796 vs. 9540

177 vs. 175

1.02

(0.80,1.30)

10,066 vs. 10,207

185 vs. 200

0.96

(0.76,1.21)

 

T3 vs. T1

9506 vs. 9540

213 vs. 175

1.24

(0.98,1.57)

10,125 vs. 10,207

232 vs. 200

1.20

(0.96,1.51)

 

Continuous

28,841

565

1.11

(1.01,1.22)

30,397

617

1.09

(0.99,1.20)

Distal colon

T2 vs. T1

9796 vs. 9540

206 vs. 190

1.07

(0.85,1.35)

10,066 vs. 10,207

120 vs. 129

0.95

(0.72,1.25)

 

T3 vs. T1

9506 vs. 9540

222 vs. 190

1.18

(0.94,1.49)

10,125 vs. 10,207

153 vs. 129

1.21

(0.93,1.58)

 

Continuous

28,841

618

1.11

(1.02,1.22)

30,397

402

1.14

(1.02,1.27)

Rectum

T2 vs. T1

9796 vs. 9540

162 vs. 159

1.00

(0.78,1.29)

10,066 vs. 10,207

88 vs. 85

1.06

(0.77,1.47)

 

T3 vs. T1

9506 vs. 9540

163 vs. 159

1.04

(0.81,1.33)

10,125 vs. 10,207

87 vs. 85

1.05

(0.76,1.44)

 

Continuous

28,841

484

1.00

(0.91,1.11)

30,397

260

1.07

(0.94,1.22)

  1. Abbreviations: CRC, colorectal cancer; CI, confidence interval; HR, hazard ratio; PT, person-time; T1-3, sex-specific tertile 1-3; vs. versus.
  2. a The polygenic risk score was composed of MTOR rs1057079, TSC2 rs1800720, TSC2 rs2516739, PDK1 rs6723872, EIF4EBP1 rs6605631, RPS6KB2 rs12787021, AKT3 rs14403, AKT3 rs3006939, AKT3 rs946824, AKT2 rs16974157, AKT2 rs874269, and INSR rs891088 in men, and of MTOR rs2295080, TSC2 rs12918803, PDK1 rs6723872, RPS6KB2 rs12787021, AKT3 rs1352162, AKT3 rs14403, AKT3 rs7523198, AKT3 rs7523742, AKT2 rs16974157, AKT2 rs874269, and INSR rs891088 in women.
  3. b Adjusted for age (years).