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Table 1 Baseline characteristics of subcohort members and CRC cases within the Netherlands Cohort Study (20.3 years of follow-up)

From: Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

 

Men

Women

 

Subcohort

CRC cases

Subcohort

CRC cases

Characteristic

N (%)

Mean (SD)

N (%)

Mean (SD)

N (%)

Mean (SD)

N (%)

Mean (SD)

Polygenic risk score a

        

Tertile 1

 

-1.06 (0.4)

 

-1.02 (0.4)

 

-1.01 (0.3)

 

-0.99 (0.3)

Tertile 2

 

-0.06 (0.3)

 

-0.05 (0.3)

 

-0.13 (0.2)

 

-0.12 (0.2)

Tertile 3

 

1.12 (0.6)

 

1.15 (0.6)

 

1.14 (0.7)

 

1.17 (0.7)

Age in years b

 

61.4 (4.2)

 

61.7 (4.1)

 

61.6 (4.3)

 

62.0 (4.1)

BMI at baseline, kg/m2 (sex-specific) b

        

Tertile 1

 

22.3 (1.4)

 

22.5 (1.2)

 

21.6 (1.4)

 

21.6 (1.4)

Tertile 2

 

24.8 (0.5)

 

24.9 (0.6)

 

24.7 (0.8)

 

24.8 (0.8)

Tertile 3

 

27.9 (1.7)

 

27.9 (2.0)

 

29.1 (2.7)

 

29.0 (2.6)

Non-occupational physical activity, min/d b

        

<=30

322 (17.8)

 

308 (16.6)

 

432 (25.6)

 

387 (27.9)

 

>30-60

576 (31.8)

 

556 (29.9)

 

541 (32.1)

 

433 (31.2)

 

>60-90

915 (50.5)

 

993 (53.5)

 

712 (42.3)

 

569 (41.0)

 

Height, cm (sex-specific) b

        

Tertile 1

 

169.4 (3.3)

 

169.2 (3.4)

 

158.9 (3.7)

 

159.1 (3.2)

Tertile 2

 

176.4 (1.6)

 

176.5 (1.5)

 

166.2 (1.5)

 

166.3 (1.5)

Tertile 3

 

184.0 (3.8)

 

184.1 (4.1)

 

172.4 (3.1)

 

172.9 (3.5)

Residence during the Hunger Winter (1944-45) b

        

Western city

903 (60.4)

 

962 (61.9)

 

911 (56.8)

 

725 (54.8)

 

Western rural area

228 (15.3)

 

232 (14.9)

 

250 (15.6)

 

223 (16.9)

 

Non-western area

364 (24.3)

 

360 (23.2)

 

442 (27.6)

 

375 (28.3)

 

Family history of CRC, yes b

98 (5.3)

 

166 (8.8)

 

94 (5.5)

 

133 (9.4)

 

Smoking status

        

Never

235 (12.1)

 

228 (12.1)

 

1010 (59.0)

 

844 (60.0)

 

Ex-smoker

957 (52.2)

 

1100 (58.5)

 

349 (20.4)

 

303 (21.5)

 

Current smoker

642 (35.0)

 

551 (29.3)

 

352 (20.6)

 

261 (18.5)

 

Alcohol intake, g/d b

        

0

250 (13.9)

 

227 (12.3)

 

512 (32.3)

 

416 (31.3)

 

0.1-29

1278 (71.1)

 

1315 (71.2)

 

1018 (64.2)

 

856 (64.4)

 

≥30

270 (15.0)

 

304 (16.5)

 

55 (3.5)

 

58 (4.4)

 

Meat intake, g/d b

 

104.7 (43.4)

 

105.4 (43.0)

 

92.5 (41.8)

 

89.6 (40.7)

Processed meat intake, g/d b

 

16.6 (17.5)

 

17.4 (17.2)

 

10.7 (12.4)

 

10.8 (11.6)

Total energy intake, kcal/d b

 

2140 (505)

 

2147 (496)

 

1658 (411)

 

1650 (388)

  1. Abbreviations: BMI, body mass index; CRC, colorectal cancer; N, number of; SD, standard deviation
  2. a The polygenic risk score was composed of MTOR rs1057079, TSC2 rs1800720, TSC2 rs2516739, PDK1 rs6723872, EIF4EBP1 rs6605631, RPS6KB2 rs12787021, AKT3 rs14403, AKT3 rs3006939, AKT3 rs946824, AKT2 rs16974157, AKT2 rs874269, and INSR rs891088 in men, and of MTOR rs2295080, TSC2 rs12918803, PDK1 rs6723872, RPS6KB2 rs12787021, AKT3 rs1352162, AKT3 rs14403, AKT3 rs7523198, AKT3 rs7523742, AKT2 rs16974157, AKT2 rs874269, and INSR rs891088 in women. Scores were standardized with a mean of 0 and an SD of 1.
  3. b Numbers and percentages or means and SDs were given after additionally excluding individuals with incomplete/inconsistent questionnaires.
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