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Table 1 Real-world pediatric drug-event detection performance. The area under the receiver operating characteristic curve (AUROC) and sensitivity or true positive rate to detect real-world pediatric drug-events observed within FAERS per each method and score type. The prediction threshold for the sensitivity was the null statistic for each method (null threshold: GAM==0; PRR==1). The performance interval is the 95% confidence interval

From: Evaluating risk detection methods to uncover ontogenic-mediated adverse drug effect mechanisms in children

 

Real-world pediatric drug-event detection performance

AUROC

Sensitivity

90mse

score

90mse

score

 

PRR

GAM

PRR

GAM

PRR

GAM

PRR

GAM

Performance value

0.62 [0.58, 0.66]

0.65 [0.59, 0.69]

0.62 [0.58, 0.67]

0.73 [0.69, 0.77]

0.28 [0.22, 0.36]

0.28 [0.23, 0.35]

0.49 [0.40, 0.56]

0.85 [0.81, 0.89]