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Table 1 Real-world pediatric drug-event detection performance. The area under the receiver operating characteristic curve (AUROC) and sensitivity or true positive rate to detect real-world pediatric drug-events observed within FAERS per each method and score type. The prediction threshold for the sensitivity was the null statistic for each method (null threshold: GAM==0; PRR==1). The performance interval is the 95% confidence interval

From: Evaluating risk detection methods to uncover ontogenic-mediated adverse drug effect mechanisms in children

  Real-world pediatric drug-event detection performance
AUROC Sensitivity
90mse score 90mse score
  PRR GAM PRR GAM PRR GAM PRR GAM
Performance value 0.62 [0.58, 0.66] 0.65 [0.59, 0.69] 0.62 [0.58, 0.67] 0.73 [0.69, 0.77] 0.28 [0.22, 0.36] 0.28 [0.23, 0.35] 0.49 [0.40, 0.56] 0.85 [0.81, 0.89]