Fig. 3

Summary of ADE detection method risk score quality. A Deviation from the normal score distributions for each method and score type across development stages. The score distributions were produced after 100 bootstraps of the original scores at each child development stage. The Shapiro-Wilk test calculated a significance probability value for the resampled scores being drawn from a normal distributions. B PRR detection method risk score quality summary. Across the positive and negative controls as well as drug event reporting dynamics classes, we calculated the number of scores with a zero, NaN (unable to be computed; the drug not reported at a stage or the drug not reported with the event at a stage), or nonzero positive score across child development stages