Fig. 1
From: Coupling sparse Cox models with clustering of longitudinal transcriptomics data for trauma prognosis
Schematic representation of the framework used in the study. Firstly, a static evaluation was performed for specific time points from the TRDB. This step includes a survival analysis based on the patient discharge from the hospital and dimensionality reduction of variables using Cox regression models. Secondly, a longitudinal evaluation for the entire time-series gene expression data of trauma patients was done. Imputation methodologies were implemented, and multivariate time series clustering was applied to profile trauma patients